An observational study with the size and level of analysis as ours is hardly achieved and infeasible to be conducted as a randomized clinical trial. Conclusions are hard to be refuted. Data is data, regardless of your beliefs. https://t.co/QeHhHxm945

— Flavio A. Cadegiani, MD, MSc, Ph.D. (@FlavioCadegiani) September 1, 2022