OHSU study reveals how low-dose melatonin taken in the afternoon helps most winter depressives whose physiological clocks are off kilter due to the later winter sunrise
Researchers at Oregon Health & Science University(OHSU) have found that melatonin, a naturally occurring brain substance, can relieve the doldrums of winter depression, also known as seasonal affective disorder, or SAD. The study is publishing online this week in the Proceedings of the National Academy of Science.
The study was led by Alfred Lewy, M.D., Ph.D., an internationally recognized pioneer in the study of circadian (24-hour) rhythm disturbances, such as those found in air travelers and shift workers, as well as in totally blind people.
Psychopaths have physical abnormalities in two key brain structures responsible for functions ranging from fear detection to information processing, a USC clinical neuroscientist has found in two studies that suggest a neuro-developmental basis to the disorder.
Adrian Raine, a professor of psychology and neuroscience in the USC College of Letters, Arts & Sciences, focused his research on two parts of the brain: the hippocampus, a portion of the temporal lobe that regulates aggression and transfers information into memory; and the corpus callosum, a bridge of nerve fibers that connects the cerebral hemispheres.
"Scientists have implicated different brain regions with respect to antisocial and aggressive behavior, and all are important and relevant," Raine said.
"But it goes beyond that to the wiring. Unless these parts of the brain are properly wired together, they'll never communicate effectively. They'll never result in appropriate behavior," he said.
Although the neurobiological roots of psychopathy are still being explored, the key behavioral features of a psychopath have been clearly defined.
Carnegie Mellon University neuroscientist Marcel Just and Stanford postdoctoral fellow Sashank Varma have put forward a new computational theory of brain function that provides answers to one of the central questions of modern science: How does the human brain organize itself to give rise to complex cognitive tasks such as reading, problem solving and spatial reasoning? Just and Varma's theory, called 4CAPS, is described in the fall issue of the journal Cognitive, Affective, and Behavioral Neuroscience.
More than a decade of research involving functional Magnetic Resonance Imaging brain scans in hundreds of laboratories has yielded a tremendous amount of information about what parts of the brain are activated when a person performs various tasks. Some researchers have been tempted to conclude that a simple one-to-one relationship exists between high-level mental tasks and brain areas. For example, some believe that a specific brain area is responsible for a specific cognitive task, such as identifying a face.
Gary Null, PhD; Carolyn Dean MD, ND; Martin Feldman, MD; Debora Rasio, MD; and Dorothy Smith, PhD Life Extension Foundation Sat, 07 Jul 2007 05:18 UTC
"A group of researchers meticulously reviewed the statistical evidence and their findings are absolutely shocking. These researchers have authored a paper titled "Death by Medicine" that presents compelling evidence that today's system frequently causes more harm than good.
The most stunning statistic, however, is that the total number of deaths caused by conventional medicine is an astounding 783,936 per year. It is now evident that the American medical system is the leading cause of death and injury in the US. (By contrast, the number of deaths attributable to heart disease in 2001 was 699,697, while the number of deaths attributable to cancer was 553,251)"
Scores of grumbling parents facing a threat of jail lined up at a courthouse Saturday to either prove that their school-age kids already had their required vaccinations or see that the youngsters submitted to the needle.
Parents and children wait in line in front of Prince George's Circuit Court, Saturday, Nov. 17, 2007, in Upper Marlboro, Md. Parents in Prince George's County have been ordered to appear at a special court hearing Saturday where they will be given a choice: Get their children vaccinated on the spot or risk up to 10 days in jail and fines.
Researchers at the University of Rochester Medical Center in New York state have identified a compound that eliminates myotonia -- a symptom of muscular dystrophy -- in mice.
In people with myotonic dystrophy, a critical cellular mechanism that controls electrical activity in muscles is essentially disabled and muscle cells (such as those shown above) cannot relax properly.
Sunny days! The earliest episodes of "Sesame Street" are available on digital video! Break out some Keebler products, fire up the DVD player and prepare for the exquisite pleasure-pain of top-shelf nostalgia.
Just don't bring the children. According to an earnest warning on Volumes 1 and 2, "Sesame Street: Old School" is adults-only: "These early 'Sesame Street' episodes are intended for grown-ups, and may not suit the needs of today's preschool child."
Researchers have identified brain structures that process the threat of punishment for violating social norms. They said that their findings suggest a neural basis for treating children, adolescents, and even immature adults differently in the criminal justice system, since the neural circuitry for processing the threat of such punishment is not as developed in younger individuals as it is in adults. The researchers also said that their identification of the brain's "social norm compliance" structures also opens the way to exploring whether psychopaths have deficiencies in these structures' circuitry.
Manfred Spitzer, Ernst Fehr, and colleagues published their findings in the October 4, 2007 issue of the journal Neuron, published by Cell Press.
It's well known that the body's energy levels cycle on a 24-hour, or circadian, schedule, and that this metabolic process is fueled by oxygen. Now, researchers at the University of Pennsylvania School of Medicine have found that a protein called Rev-erb coordinates the daily cycles of oxygen-carrying heme molecules to maintain the body's correct metabolism.
The research appears online this week in Science Express in advance of print publication in Science.
Many studies, including this one, point to a link between the human internal clock and such metabolic disorders as obesity and diabetes. Proteins such as Rev-erb are the gears of the clock and understanding their role is important for fighting these diseases.
A multinational team of researchers has shown for the first time that the immune system can stop the growth of a cancerous tumor without actually killing it.
Scientists have been working for years to use the immune system to eradicate cancers, a technique known as immunotherapy. The new findings prove an alternate to this approach exists: When the cancer can't be killed with immune attacks, it may be possible to find ways to use the immune system to contain it. The results also may help explain why some tumors seem to suddenly stop growing and go into a lasting period of dormancy.
The study appears today in the advance online publication of Nature.
"We have about 50% of the world's wealth but only 6.3% of its population. This disparity is particularly great as between ourselves and the peoples of Asia. In this situation, we cannot fail to be the object of envy and resentment. Our real task in the coming period is to devise a pattern of relationships which will permit us to maintain this position of disparity without positive detriment to our national security. To do so, we will have to dispense with all sentimentality and day-dreaming; and our attention will have to be concentrated everywhere on our immediate national objectives. We need not deceive ourselves that we can afford today the luxury of altruism and world-benefaction."
~ US State Department, 1948
- George Kennan
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"It may be the first piece of evidence that people in the West have made a decision to liquidate him. Be afraid, clown!" Seems about right to...
Comment: Here is a little reminder of the by-gone days of trash loving. Nowadays, we sweep it under the carpet.
Sesame Street - I Love Trash (1969)