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Paxlovid and heart medications don't interact well

paxlovid
© Nick Zonna/IPA/SIPA
Heart disease patients with symptomatic COVID-19 are often treated with nirmatrelvir-ritonavir (Paxlovid) to prevent progression to severe disease; however, it can interact with some previously prescribed medications. A review paper published today in the Journal of the American College of Cardiology examines the potential drug-drug interactions (DDIs) between Paxlovid and commonly used cardiovascular medications, as well as potential options to mitigate severe adverse effects.

"Awareness of the presence of drug-drug interactions of Paxlovid with common cardiovascular drugs is key. System-level interventions by integrating drug-drug interactions into electronic medical records could help avoid related adverse events," said Sarju Ganatra, MD, director of the cardio-oncology program at Lahey Hospital and Medical Center in Burlington, Massachusetts, and the senior author of the review. "The prescription of Paxlovid could be incorporated into an order set, which allows physicians, whether it be primary care physicians or cardiology providers, to consciously rule out any contraindications to the co-administration of Paxlovid. Consultation with other members of the health care team, particularly pharmacists, can prove to be extremely valuable. However, a health care provider's fundamental understanding of the drug-drug interactions with cardiovascular medications is key."

Comment: So basically, it's not only ineffective, but it could be extremely harmful, if not deadly. Are we surprised? See also:


Health

COVID-19 much less deadly than previously thought, major study finds

Dr. John Ioannidis
COVID-19 is much less deadly in the non-elderly population than previously thought, a major new study of antibody prevalence surveys has concluded.

The study was led by Dr. John Ioannidis, Professor of Medicine and Epidemiology at Stanford University, who famously sounded an early warning on March 17th 2020 with a widely-read article in Stat News, presciently arguing that "we are making decisions without reliable data" and "with lockdowns of months, if not years, life largely stops, short-term and long-term consequences are entirely unknown, and billions, not just millions, of lives may be eventually at stake".

In the new study, which is currently undergoing peer-review, Prof. Ioannidis and colleagues found that across 31 national seroprevalence studies in the pre-vaccination era, the average (median) infection fatality rate of COVID-19 was estimated to be just 0.035% for people aged 0-59 years and 0.095% for those aged 0-69 years. A further breakdown by age group found that the average IFR was 0.0003% at 0-19 years, 0.003% at 20-29 years, 0.011% at 30-39 years, 0.035% at 40-49 years, 0.129% at 50-59 years, and 0.501% at 60-69 years.

Comment: See also:


Alarm Clock

"The spike in heart attacks has coincided with the vaccinations": An emergency department doctor on what's behind the NHS crisis

emergency room patient
An account from the frontlines of the NHS

As Emergency Department doctors, we were always going to be on the frontline. In spring 2020, we were taken to one side and it was suggested we might have to say goodbye to our relatives for the foreseeable future. Few realise the fear generated in hospitals in 2020. As Emergency Department consultants we were put on 24/7 emergency shift rotas and provided with vacant hotel rooms to live away from our families for their protection. Many of our colleagues left us to it and, soon after, patients arrived showing us signs that had been put up on their GP's door saying "closed due to the pandemic".

Spring 2020 saw a combination of assessing and treating sick patients who had unusual and characteristic presentations of Covid in an otherwise quiet Emergency Department. The less-sick patients queued in their cars for assessment in the rapidly delivered 'Covid-pod'. Huge hospital Covid signage was hastily erected. Doctors were redeployed to work in the Emergency Department from other specialties that were literally cancelled or scaled back hugely. I had one come to me at midnight asking why there were twice as many doctors in the place as patients; that he was bored and hadn't seen a patient for three hours. Pre-lockdowns we were seeing over 300 patients each day. During the lockdown madness this dropped to less than 100 on some days. Many patients were petrified at the idea of coming to hospital. Others were instructed to stay away from the hospital unless extremely ill. This went on for months. Then the patients gradually came back, some with essentially no other access to healthcare. The department has not been quiet for some time now.

Health

Florida recommends against mRNA vaccination for males aged 18-39 due to 84% increase in heart death risk

florida
Florida's State Surgeon General Dr. Joseph A. Ladapo has recommended against males aged 18 to 39 receiving mRNA COVID-19 vaccines owing to an 84% increase in the incidence of heart-related death within 28 days following mRNA vaccination. Here is the press release.
Today, State Surgeon General Dr. Joseph A. Ladapo has announced new guidance regarding mRNA vaccines. The Florida Department of Health (Department) conducted an analysis through a self-controlled case series, which is a technique originally developed to evaluate vaccine safety.

This analysis found that there is an 84% increase in the relative incidence of cardiac-related death among males 18-39 years old within 28 days following mRNA vaccination. With a high level of global immunity to COVID-19, the benefit of vaccination is likely outweighed by this abnormally high risk of cardiac-related death among men in this age group. Non-mRNA vaccines were not found to have these increased risks.

Muffin

New study: Eating late increases hunger, decreases calories burned, and changes fat tissue

Late eating
Obesity afflicts approximately 42 percent of the U.S. adult population and contributes to the onset of chronic diseases, including diabetes, cancer, and other conditions. While popular healthy diet mantras advise against midnight snacking, few studies have comprehensively investigated the simultaneous effects of late eating on the three main players in body weight regulation and thus obesity risk: regulation of calorie intake, the number of calories you burn, and molecular changes in fat tissue.

A new study by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, found that when we eat significantly impacts our energy expenditure, appetite, and molecular pathways in adipose tissue. Their results are published in Cell Metabolism.

Comment: See also:


Syringe

UNFORGIVABLE: At least 163 Children dead, 1.2k disabled, 15k hospitalised & 58k injured due to Covid-19 Vaccination in the USA according to CDC

Covid Vaccination for children.
© REUTERS/Jon Cherry
The latest figures published by the USA's Centers for Disease Control reveal nearly 58,000 children have been injured due to Covid-19 vaccination across the USA, and sadly 1,201 of these children either suffered a life-threatening event or a permanent disability, while tragically a further 163 children have sadly lost their lives as of September 29th, 2022.

The Centers for Disease Control (CDC) hosts a Vaccine Adverse Event Reporting System (VAERS) that is updated weekly and can be found here.

Unfortunately, the CDC reveals that at least 57,622 children (Aged 0 to 17) have suffered an injury due to Covid-19 vaccination as of September 29th 2022.
CDC covid vaccine injury

Microscope 1

Why did the coronavirus suddenly cause thousands of deaths in spring 2020 when it had been hanging around quietly all winter?

COVID, nurse, hospital
There is now no shortage of evidence that the coronavirus had begun spreading undetected all over the world by autumn 2019 at the latest. However, the 2019-20 flu season was mild in most places. For instance, here is U.S. mortality, with the 2019-20 flu season circled.
deaths from COVID
And here is England and Wales, with the unremarkable end of winter 2019-20 on the left hand side (before week 10). The contrast with the spring surge (and subsequent waves) is obvious.
England and Wales excess mortality
This leads to a mystery: why did COVID-19 only start killing lots of people come spring 2020 if it had been hanging around quietly all winter?

Syringe

Government forced to launch investigation into rise in newborn deaths since the COVID vaccine was approved thanks to exclusive investigation carried out by The Exposé

mother, baby, newborn, child, infant, breastfeeding
© Catherine Delahaye/Getty Images
Recently, an exclusive investigation carried out by the team at The Exposé forced the European Union to launch a Europe-wide investigation into why so many children have died and are still dying since the European Medicines Agency first approved the Covid-19 vaccine for children.

Now a second investigation conducted by the team at The Exposé has forced the Scottish Government to launch a country-wide investigation into why so many newborn baby deaths have occurred across the country since Government & Health Officials outrageously claimed the Covid-19 vaccine was safe for pregnant women without any evidence to back up those claims whatsoever.

Comment: See also: TWO spikes of newborn baby deaths in Scotland under investigation


Syringe

Three vaccine doses increase infection risk by up to 27%, study finds

moderna vaccine bottle syringe
Three doses of the Moderna Covid vaccine increase your risk of Omicron infection by up to 27%, a study has found.

The pre-print study (not yet peer-reviewed) was funded by Moderna itself and partly designed by employees of Moderna as well as involving researchers from Kaiser Permanente in Southern California. The study's reporting of poor outcomes for the original vaccine may be understood in the context of Moderna now having a 'bivalent vaccine' which targets Omicron.

The study used a test-negative case-control design to evaluate the Moderna Covid vaccine's effectiveness against infection and hospitalisation with Omicron subvariants. It included 30,809 test-positive and 92,427 test-negative individuals aged over 18 years tested during the first half of 2022. Results were adjusted for potential confounders such as age, sex and comorbidities.

Comment: We'd be willing to bet it's the latter "more general inhibition of the immune system." Remember a couple of months back when the vaccines were being tied to acquired immunodeficiency? See: See also:


Beaker

Not a placebo: Scientific evidence exists for homeopathy

apothecary
© Shutterstock
Getting through the most difficult times of COVID, it has become increasingly clear that the key to enhancing our good health is by boosting and balancing our own immunity. We are not necessarily promoting the precise therapies of homeopathy, but rather offering a different angle of understanding the subtleness and multi-faceted nature of the human body.

An article titled "Homeopathy" published in 1989 in Yoga Journal described one case in which a woman suffering from lupus was cured by homeopathy.

After years of unsuccessful conventional treatment, the lady enlisted the help of a homeopathic physician. The first step was to treat her drug dependency and relieve her pericarditis. She was prescribed a homeopathic dose of Cactus grandiflorus, which would produce heart palpitations and depression in healthy people. However, in her case, the Cactus grandiflorus reduced the inflammation caused by pericarditis.

Comment: See also: