© Hawrot Lab/Brown UniversityResearchers have found that the alpha-7 receptor, a site known to bind with nicotine, interacts with 55 different proteins. Nicotine may affect bodily processes -- and perhaps the actions of other commonly used drugs -- more broadly than was previously thought.
Nicotine isn't just addictive. It may also interfere with dozens of cellular interactions in the body, new Brown University research suggests.
Conversely, the data could also help scientists develop better treatments for various diseases. Pharmaceutical companies rely on basic research to identify new cellular interactions that can, in turn, serve as targets for potential new drugs.
"It opens several new lines of investigation," said lead author Edward Hawrot, professor of molecular science, molecular pharmacology, physiology and biotechnology at Brown University.
Hawrot's research is highlighted in a paper published April 3 in the
Journal of Proteome Research. He and a team that included graduate students William Brucker and Joao Paulo set out to provide a more basic understanding of how nicotine affects the process of cell communication through the mammalian nervous system.
Comment: Notice that the article makes no mention of whether the interaction of nicotine with the alpha-7 receptor is negative or not. And that it shows promising research possibiities with respect to treating schizophrenia. Yet this substance, which has been in use for thousands years by indigenous peoples is still demonized. Why?
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Let's All Light Up!