A challenging goal in biology is to understand how the principal cellular functions are integrated so that cells achieve viability and optimal fitness under a wide range of nutritional conditions. Scientists from the French research centers INRA and CNRS showed by genetic approaches that, in the model bacterium Bacillus subtilis, central carbon metabolism (which generates energy from nutrients) and replication (which synthesizes DNA), two key functions in the fields of nutrition and heredity, are tightly linked. The results appear in the May 16th issue of the online, peer-reviewed, open-access journal PLoS ONE.
The discovered link involves the activity of a small region of the central carbon metabolism (the terminal reactions of a process called glycolysis that burns sugars) and several enzymes of the replication machinery that synthesizes DNA. It is proposed that the link depends on metabolic signals generated as a function of the activity of the terminal reactions of glycolysis which are sensed, directly or indirectly, by replication enzymes. This system would then adjust the speed of DNA synthesis and the stability of the replication machinery to the nutritional richness of the environment, and thus to the cell's growth rate.
University of California, Irvine researchers have developed the first images of the physical changes in brain cells thought to underlie memory, a discovery that is already uncovering clues about memory loss linked to cognitive disorders.
Three decades of work by neuroscientists have established that a physiological effect known as long-term potentiation (LTP) encodes everyday forms of memory. In the Journal of Neuroscience today, a UC Irvine research team led by neuroscientists Christine M. Gall and Gary Lynch presents these unique images, which show that the size and shape of synapses were changed by LTP.
"The way is now open to mapping where in the brain memories are laid down," said Lynch, a professor of psychiatry and human behavior. "Seeing memory-related physical changes to synapses means that we can at last use mouse models to test if the effects of retardation, aging and various cognitive disorders involve a specific, long-suspected defect in the connections between cortical neurons."
Children who are hyperactive tend to do worse academically than their peers who are not hyperactive. Although the relationship between such behaviors as overactivity, impulsivity, and inattentiveness in children and poor achievement in math, reading, language, and other areas has been well documented, little is known about the reasons for this link. New research shows that the tie may be due to genetic influences.
The study, conducted by researchers at Boston University and at the Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry in London, appears in the May/June 2007 issue of the journal Child Development. The researchers examined the extent to which common genetic and environmental factors operate across hyperactivity and achievement in nearly 2,000 7-year-old pairs of twins taking part in the U.K.-based Twins Early Development Study. In the study, both parents and teachers provided ratings of twins' hyperactive behavior problems (e.g., restlessness, fidgeting, distractibility, impulsivity, and attention span). Academic achievement was based on teacher assessments of English and mathematics skills conducted at the end of the first year of primary school (equivalent to first grade in the United States).
Undisclosed industry funding, unsubstantiated conclusions on vaccines, and study sample alteration undermine credibility on controversial topic
A recent press release from the University of Missouri announced the results of a study on autism and Rh immune globulin (RhIg) injections, some of which contained a mercury preservative called thimerosal. SafeMinds reviewed information about this study and found several troublesome aspects, including undisclosed industry funding, unsubstantiated conclusions on vaccines and mercury, and deviation from acceptable scientific practice.
Ines Ehrlich
YnetThu, 17 May 2007 07:52 UTC
The IDF secretly used elite combat soldiers as "guinea pigs" for experimental anthrax vaccines, according to an expose broadcast Wednesday night by the "Uvda" (Fact) documentary program.
Presenter Ilana Dayan revealed how in 2000, the army decided to carry out anthrax antibody experiments ahead of independent manufacture in Israel.
According to the report, hundreds of young recruits into Israel's elite combat units were offered the opportunity to partake in a top secret experiment codenamed "Omer 2". They were led to believe they were performing a national service of the utmost importance to the state.
The soldiers were told that the antibody had been approved by the American FDA as far back as 1970 and was used on thousands of American military personnel. It was explained that the experiment they would undergo constituted the final phase prior to anthrax vaccine production in Israel, which would cater to a possible eventuality of a biological attack on military or civilian populations.
STRATHMORE, Calif. - On Grandparents Day, Domitila Lemus accompanied her 8-year-old granddaughter to school. As the girls lined up behind Sunnyside Union Elementary, a foul mist drifted onto the playground from the adjacent orange groves, witnesses say. Lemus started coughing, and two children collapsed in spasms, vomiting on the blacktop.
Getting off the couch and accepting low-grade pain may be one of the keys to improved function in back pain.
The intervention that shows the most benefit? Keeping active. Millions of dollars of research to tell us that "motion is lotion, baby." Not as in moving propane tanks or other heavy activity that makes the pain worse, but just keeping moving.
While regular multivitamin use is not linked with early or localized prostate cancer, taking too many multivitamins may be associated with an increased risk for advanced or fatal prostate cancers, according to a study in the May 16 issue of the Journal of the National Cancer Institute.
Guy Faulconbridge
ReutersTue, 15 May 2007 12:22 UTC
MOSCOW (Reuters) - Russia's AIDS epidemic is worsening with as many as 1.3 million people infected with HIV as the virus spreads further into the heterosexual population, Russia's top AIDS specialist said on Tuesday.
One of the issues of a New York medical bulletin dating back to 1888 contains description of an amazing case of a sailor who was badly injured while on duty. The sailor worked at a river tugboat. One day his tugboat was towing a barge loaded with bulky boxes, which were stacked on the deck in two tiers, one above the other. The sailor was positioned on the bow of the barge as his tugboat was nearing a bridge with a low archway. By some unfortunate twist of fate, the sailor decided to check lashings on the top level boxes at that point. He stuck his head above the boxes and began examining the lashings. His eyes were looking aft as the tugboat moved up closer to the bridge. The sailor was completely unaware of the imminent danger looming a few yards away. A sharp-edged lower beam of the bridge span ran against the sailor's head, cutting a sizeable piece off his skull, approximately two inches above his right eye.
The rest of the story reads like a miracle.
