Blockbusters are expiring, pipelines are emptying and watchdogs are growling
The pharmaceutical industry is under siege with the looming end of blockbuster drugs, imminent patent expiries on top-selling medicines and government pressure to lower prices amid accusations of profiteering.
GlaxoSmithKline's new boss, Andrew Witty, has likened discovering a blockbuster - with annual revenues of at least $1bn - to finding a needle in a haystack. Many of the big-selling medicines launched in the 1990s are about to come off patent, allowing generic drugmakers to make cheaper versions. Only four of the 10 major companies have enough products in their pipeline to plug the looming revenue shortfall.
Health & Wellness
Reducing levels of uric acid in blood lowered blood pressure to normal in most teens in a study designed to investigate a possible link between blood pressure and the chemical, a waste product of the body's normal metabolism, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of the American Medical Association.
"If you reduce uric acid, at least in some patients, you may be able to reduce blood pressure," said Dr. Daniel Feig, associate professor of pediatrics-renal at BCM and chief of the pediatric hypertension clinics at Texas Children's Hospital. "This could be one way people develop hypertension and may allow us to develop new therapies."
Understanding how people develop high blood pressure gives scientists new tools for understanding the disorder and developing drugs to prevent and treat it.
"If you reduce uric acid, at least in some patients, you may be able to reduce blood pressure," said Dr. Daniel Feig, associate professor of pediatrics-renal at BCM and chief of the pediatric hypertension clinics at Texas Children's Hospital. "This could be one way people develop hypertension and may allow us to develop new therapies."
Understanding how people develop high blood pressure gives scientists new tools for understanding the disorder and developing drugs to prevent and treat it.
Finnish scientists have identified genes that may predispose to anxiety disorders. Research conducted under the supervision of Academy Research Fellow Iiris Hovatta have focused on genes that influence human behaviour, and some of the studied genes show a statistical association with specific anxiety disorders. The work is carried out as part of the Academy of Finland Research Programme on Neuroscience (NEURO).
You might call Maarten van der Weijden the anti-Lance Armstrong. Last week, the Dutch Olympic long-distance swimming champion and cancer survivor told the British newspaper The Telegraph that he didn't want to be compared to the American cycling star.
"Armstrong says that positive thinking and doing a lot of sports can save you. I don't agree," said van der Weijden. "I even think it's dangerous because it implies that if you are not a positive thinker all the time you lose ... The doctors saved me. I am just lucky."
"Armstrong says that positive thinking and doing a lot of sports can save you. I don't agree," said van der Weijden. "I even think it's dangerous because it implies that if you are not a positive thinker all the time you lose ... The doctors saved me. I am just lucky."
A deficiency of B-vitamins may cause vascular cognitive impairment, according to a new study. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University used an experimental model to examine the metabolic, cognitive, and microvascular effects of dietary B-vitamin deficiency.
"Metabolic impairments induced by a diet deficient in three B-vitamins -folate, B12 and B6- caused cognitive dysfunction and reductions in brain capillary length and density in our mouse model," says Aron Troen, PhD, the study's lead author. "The vascular changes occurred in the absence of neurotoxic or degenerative changes."
Troen, who is an assistant professor at Tufts University's Friedman School of Nutrition Science and Policy, explains, "Mice fed a diet deficient in folate and vitamins B12 and B6 demonstrated significant deficits in spatial learning and memory compared with normal mice." Troen and colleagues observed similar but less pronounced differences between normal mice and a third group of mice that were fed a diet enriched with methionine.
"Metabolic impairments induced by a diet deficient in three B-vitamins -folate, B12 and B6- caused cognitive dysfunction and reductions in brain capillary length and density in our mouse model," says Aron Troen, PhD, the study's lead author. "The vascular changes occurred in the absence of neurotoxic or degenerative changes."
Troen, who is an assistant professor at Tufts University's Friedman School of Nutrition Science and Policy, explains, "Mice fed a diet deficient in folate and vitamins B12 and B6 demonstrated significant deficits in spatial learning and memory compared with normal mice." Troen and colleagues observed similar but less pronounced differences between normal mice and a third group of mice that were fed a diet enriched with methionine.
Middle school children who have a television or computer in their room sleep less during the school year, watch more TV, play more computer games and surf the net more than their peers who don't - reveals joint research conducted by the University of Haifa and Jezreel Valley College.
The research, conducted by Prof. Yael Latzer and Dr. Tamar Shochat of the University of Haifa and Prof. Orna Chishinsky of the Jezreel Valley College, examined 444 middle school pupils with an average age of 14. The children were asked about their sleep habits, their use of computer and television, and their eating habits while watching TV or using the computer.
The study participants reported an average bedtime of 11:04 P.M and wake-up time of 6:45 A.M. On the weekends, the average bedtime was somewhat later - at 1:45 A.M. and wake-up much later - at 11:30 A.M. Those children with TVs or computers in their room went to sleep half an hour later on average but woke up at the same time.
According to the study, middle school pupils watch a daily average of two hours and 40 minutes of TV and use their computer for three hours and 45 minutes. On weekends, they watch half an hour more TV than during the rest of the week and use their computers for four hours. Children with a TV in their room watch an hour more than those without and those with their own computer use it an hour more than their peers.
The research, conducted by Prof. Yael Latzer and Dr. Tamar Shochat of the University of Haifa and Prof. Orna Chishinsky of the Jezreel Valley College, examined 444 middle school pupils with an average age of 14. The children were asked about their sleep habits, their use of computer and television, and their eating habits while watching TV or using the computer.
The study participants reported an average bedtime of 11:04 P.M and wake-up time of 6:45 A.M. On the weekends, the average bedtime was somewhat later - at 1:45 A.M. and wake-up much later - at 11:30 A.M. Those children with TVs or computers in their room went to sleep half an hour later on average but woke up at the same time.
According to the study, middle school pupils watch a daily average of two hours and 40 minutes of TV and use their computer for three hours and 45 minutes. On weekends, they watch half an hour more TV than during the rest of the week and use their computers for four hours. Children with a TV in their room watch an hour more than those without and those with their own computer use it an hour more than their peers.
A study of Crohn's disease and ulcerative colitis in children has identified a gene that influences whether children get these diseases early in life, and points to a potential new target for treatment.
Crohn's disease and ulcerative colitis are chronic inflammatory diseases that affect the intestines, resulting in pain, severe diarrhea, intestinal bleeding, weight loss and fever. In ulcerative colitis, the inner lining of the colon is inflamed, while in Crohn's disease the inflammation extends deeper into the intestinal wall and can involve both the small and large intestine.
While several genes that influence susceptibility to the two diseases have been found previously, this study is the first to focus on inflammatory bowel disease (IBD) with childhood onset, says co-first author Subra Kugathasan, MD.
Crohn's disease and ulcerative colitis are chronic inflammatory diseases that affect the intestines, resulting in pain, severe diarrhea, intestinal bleeding, weight loss and fever. In ulcerative colitis, the inner lining of the colon is inflamed, while in Crohn's disease the inflammation extends deeper into the intestinal wall and can involve both the small and large intestine.
While several genes that influence susceptibility to the two diseases have been found previously, this study is the first to focus on inflammatory bowel disease (IBD) with childhood onset, says co-first author Subra Kugathasan, MD.
It's the opposite of a vicious cycle: Healthy people might be happier, and a new study shows that people who are happy and satisfied with their lives might be healthier.
Moreover, the benefit comes with a quick turnaround time, with greater happiness possibly boosting health in as little as three years.
"Everything else being equal, if you are happy and satisfied with your life now, you are more likely to be healthy in the future. Importantly, our results are independent of several factors that impact on health, such as smoking, physical activity, alcohol consumption and age," said lead author Mohammad Siahpush, Ph.D.
Moreover, the benefit comes with a quick turnaround time, with greater happiness possibly boosting health in as little as three years.
"Everything else being equal, if you are happy and satisfied with your life now, you are more likely to be healthy in the future. Importantly, our results are independent of several factors that impact on health, such as smoking, physical activity, alcohol consumption and age," said lead author Mohammad Siahpush, Ph.D.
Body weight and fertility have long known to be related to each other - women who are too thin, for example, can have trouble becoming pregnant. Now, a master switch has been found in the brain of mice that controls both, and researchers at the Salk Institute for Biological Studies say it may work the same way in humans.
Findings from the study, published ahead of print in the Aug. 31 online edition of Nature Medicine, suggest that variations in the gene that produces this master switch, known as TORC1, could contribute a genetic component to obesity and infertility, and might be regulated with a novel drug.
"This gene is crucial to the daisy chain of signals that run between body fat and the brain," says Marc Montminy, Ph.D., a professor in the Clayton Foundation Laboratories for Peptide Biology, who led the study. "It likely plays a pivotal role in how much we, as humans, eat and whether we have offspring."
Findings from the study, published ahead of print in the Aug. 31 online edition of Nature Medicine, suggest that variations in the gene that produces this master switch, known as TORC1, could contribute a genetic component to obesity and infertility, and might be regulated with a novel drug.
"This gene is crucial to the daisy chain of signals that run between body fat and the brain," says Marc Montminy, Ph.D., a professor in the Clayton Foundation Laboratories for Peptide Biology, who led the study. "It likely plays a pivotal role in how much we, as humans, eat and whether we have offspring."
These emotions are a constant for the poverty-stricken. New ideas are emerging to combat the long-term effects.
Raised in poverty, Dr. Shauna Blake Collins fought fear during nearly 14 years of education. A dropout from a South-Central Los Angeles high school, she earned a GED diploma at 22, became a licensed vocational nurse, a registered nurse, and finally, at 41, a physician. Confidence came only during the last two years of medical school.
Raised in poverty, Dr. Shauna Blake Collins fought fear during nearly 14 years of education. A dropout from a South-Central Los Angeles high school, she earned a GED diploma at 22, became a licensed vocational nurse, a registered nurse, and finally, at 41, a physician. Confidence came only during the last two years of medical school.
