Health & WellnessS


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Scientists Find Molecular Trigger that Helps Prevent Aging and Disease

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© iStockphotoNew research has unraveled a molecular puzzle to determine that within certain parameters, a lower-calorie diet slows the development of some age-related conditions such as Alzheimer's disease, as well as the aging process.
Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How does dietary restriction produce protective effects against aging and disease? And the reverse: how does overconsumption accelerate age-related disease?

An answer lies in a two-part study led by Charles Mobbs, PhD, Professor of Neuroscience and of Geriatrics and Palliative Medicine at Mount Sinai School of Medicine, published in the November 17 edition of the journal PLoS Biology. The study examines how dietary restriction and a high-caloric diet influence biochemical responses.

Dr. Mobbs and his colleagues unraveled a molecular puzzle to determine that within certain parameters, a lower-calorie diet slows the development of some age-related conditions such as Alzheimer's disease, as well as the aging process. How the diet is restricted -- whether fats, proteins or carbohydrates are cut -- does not appear to matter. "It may not be about counting calories or cutting out specific nutrients," said Dr. Mobbs, "but how a reduction in dietary intake impacts the glucose metabolism, which contributes to oxidative stress." Meanwhile, a high calorie diet may accelerate age-related disease by promoting oxidative stress.

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Analyzing Structural Brain Changes in Alzheimer's Disease

In a study that promises to improve diagnosis and monitoring of Alzheimer's disease, scientists at the University of California, San Diego have developed a fast and accurate method for quantifying subtle, sub-regional brain volume loss using magnetic resonance imaging (MRI).

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© University of California, San Diego, UCSDSerial MRI brain scans, taken six months apart, show progression from mild cognitive impairment to Alzheimer's disease, with significant atrophy (blue) and ventricle enlargement (orange/red).
The study will be published the week of November 16 in the Proceedings of the National Academy of Sciences (PNAS).

By applying the techniques to the newly completed dataset of the multi-institution Alzheimer's Disease Neuroimaging Initiative (ADNI), the scientists demonstrated that such sub-regional brain volume measurements outperform available measures for tracking severity of Alzheimer's disease, including widely used cognitive testing and measures of global brain-volume loss.

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How the Brain Filters Out Distracting Thoughts to Focus on a Single Bit of Information

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© The Norwegian University of Science and TechnologyLaura Colgin is a postdoctoral fellow at the Norwegian University of Science and Technology's Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory.
The human brain is bombarded with all kinds of information, from the memory of last night's delicious dinner to the instructions from your boss at your morning meeting. But how do you "tune in" to just one thought or idea and ignore all the rest of what is going on around you, until it comes time to think of something else?

Researchers at the Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory at the Norwegian University of Science and Technology (NTNU) have discovered a mechanism that the brain uses to filter out distracting thoughts to focus on a single bit of information. Their results are reported in 19 November issue of Nature.

Think of your brain like a radio: You're turning the knob to find your favorite station, but the knob jams, and you're stuck listening to something that's in between stations. It's a frustrating combination that makes it quite hard to get an update on swine flu while a Michael Jackson song wavers in and out. Staying on the right frequency is the only way to really hear what you're after. In much the same way, the brain's nerve cells are able to "tune in" to the right station to get exactly the information they need, says researcher Laura Colgin, who was the paper's first author. "Just like radio stations play songs and news on different frequencies, the brain uses different frequencies of waves to send different kinds of information," she says.

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How Coughing is Triggered by Environmental Irritants

Scientists have revealed how environmental irritants such as air pollution and cigarette smoke cause people to cough, in research published November 23 in the American Journal of Respiratory and Critical Care Medicine. The authors of the study, from Imperial College London and the University of Hull, have identified the reaction inside the lungs that can trigger coughing when a person is exposed to particular irritants in the air. They suggest that their findings may ultimately lead to the development of new treatments for chronic coughing.

Coughing is the most common reason for people visiting a family doctor. Treatment options are limited for people with chronic coughing; a recent study concluded that over-the-counter remedies are ineffective and there is increasing concern about the safety of these therapies in children.

This new study indicates, for the first time, how coughing can be triggered when a person is exposed to certain irritants in the air. It shows that the irritants can switch on receptor proteins called TRPA1 on the surface of nerve endings in the lungs. This switches on sensory nerves, which then trigger a cough reflex. The researchers say coughing could potentially be treated by blocking TRPA1 receptors, to stop irritants in the air from setting off this chain reaction. They hope that this could ultimately help millions of people whose lives are affected by chronic coughing.

Einstein

Researcher's labour of love leads to MS breakthrough

Elena Ravalli was a seemingly healthy 37-year-old when she began to experience strange attacks of vertigo, numbness, temporary vision loss and crushing fatigue. They were classic signs of multiple sclerosis, a potentially debilitating neurological disease.

It was 1995 and her husband, Paolo Zamboni, a professor of medicine at the University of Ferrara in Italy, set out to help. He was determined to solve the mystery of MS - an illness that strikes people in the prime of their lives but whose causes are unknown and whose effective treatments are few.

What he learned in his medical detective work, scouring dusty old books and using ultra-modern imaging techniques, could well turn what we know about MS on its head: Dr. Zamboni's research suggests that MS is not, as widely believed, an autoimmune condition, but a vascular disease.

Coffee

US could ban caffeine-alcohol drinks within months

The US Food and Drug Administration is unimpressed by the fad for drinks that contain a double hit - alcohol and caffeine. Unless makers supply the FDA with scientific evidence that the drinks are safe they could be banned within months.

The agency is worried that consuming the drinks - which can mask the effect of alcohol - leads to rash behaviour, car crashes, violence and assaults. The FDA issued the ultimatum last week in response to a request made by the National Association of Attorneys General. "Caffeine added to alcohol poses a significant public health threat," said a task force headed by the attorney-generals of Utah, Guam and Connecticut.

The FDA allows caffeine concentrations of up to 200 parts per million in soft drinks, but adding caffeine to alcohol is unregulated. At least two of the 27 companies contacted have already withdrawn their drinks.

Gear

Why are anti-smokers afraid of the truth?

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© Unknown
Several tobacco companies in the US recently launched a lawsuit claiming new FDA legislation abridges their rights under the First Amendment to the US Constitution: the right to freedom of speech. The legislation, the Family Smoking Prevention and Tobacco Control Act, actually muzzles tobacco companies to the point where they are prohibited from telling the truth.

Despite the fact that the new legislation unequivocally places regulatory responsibility of tobacco and tobacco products in the hands of the US FDA (Food and Drug Administration), the tobacco companies are forbidden from clearly communicating that incontrovertible fact.

The Act authorizes the FDA to regulate tobacco products, including reducing or eliminating any constituents used in the manufacture or processing of tobacco, if they believe it is likely to protect public health. But, should the FDA take any action they believe will make cigarettes safer, the tobacco companies will be prohibited from truthfully telling consumers that the FDA has done so.

People

Shifting Blame is Socially Contagious

Merely observing someone publicly blame an individual in an organization for a problem -- even when the target is innocent -- greatly increases the odds that the practice of blaming others will spread with the tenacity of the H1N1 flu, according to new research from the USC Marshall School of Business and Stanford University.

Nathanael J. Fast, an assistant professor of management and organization at the USC Marshall School of Business and Larissa Tiedens, a professor of organizational behavior at Stanford, conducted four different experiments and found that publicly blaming others dramatically increases the likelihood that the practice will become viral. The reason: blame spreads quickly because it triggers the perception that one's self-image is under assault and must be protected.

The study called "Blame Contagion: The Automatic Transmission of Self-Serving Attributions" is believed to be the first to examine whether shifting blame to others is socially contagious. The results will be published in the November issue of Journal of Experimental Social Psychology.

"When we see others protecting their egos, we become defensive too," says Fast, the study's lead author. "We then try to protect our own self-image by blaming others for our mistakes, which may feel good in the moment." He adds that in the long run, such behavior could hurt one's reputation and be destructive to an organization and further to our society as a whole.

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Sweet as Can Be: How E. Coli Gets Ahead

Scientists at the University of York have discovered how certain bacteria such as Escherichia coli have evolved to capture rare sugars from their environment giving them an evolutionary advantage in naturally competitive environments like the human gut.

Microbes are well-known for their ability to grow in demanding and nutritionally poor environments, which has allowed them to colonise some of the most remote places on the planet. Bacteria living in theoretically nutrient-rich environments like the mammalian intestine face similar challenges due to intense competition between bacterial species in the intestine for the finite amount of available food.

Researchers led by Dr Gavin Thomas in the University's Department of Biology discovered that a protein present in the intestinal bacterium Escherichia coli was a unique sugar transporter.

Common sugars like glucose form a cyclic structure called a 'pyranose' when dissolved in water. All transporters for glucose recognise the pyranose form. But, for sugars such as galactose, which is commonly found in dairy produce, around 10 per cent is found in a different ring form called a 'furanose'.

Syringe

H1N1 flu vaccine producing higher anaphylactic reactions among Canadians - GlaxoSmithKline recalls shots

[T]he [Manitoba] province announced manufacturer GlaxoSmithKline had asked provinces to temporarily discontinue vaccinating Canadians from a specific batch of vaccine shipped in October.

The reason is that there has been a higher ratio of severe adverse reactions to the vaccine among Canadians than from other lots.


Winnipeg flu clinics are expected to run out of vaccine containing an adjuvant to boost its effect early today. However, vaccine without adjuvant will still be available for pregnant women and anyone aged 10 to 64 without a compromised immune system.

The province should receive more vaccine with adjuvant early next week.

Manitoba reported its second H1N1 death of the season on Thursday -- and another large increase in confirmed cases of the virus -- but there was also some good news.