University of Illinois at Chicago College of Medicine researchers have identified the important role a protein plays in the body's first line of defense in directing immune cells called neutrophils toward the site of infection or injury.
Their results are described online in the Proceedings of the National Academy of Sciences.
Neutrophils are white blood cells that are activated by chemical cues to move quickly to the site of injury or infection, where they ingest bacteria. When alerted to infection, neutrophils move by changing shape, developing a distinct front and back, sending a "foot" out in front of them, and "crawling" toward the site of infection.
Hoping to better understand the role of a protein called p55 or MPPI that they had previously identified as highly expressed in neutrophils, the UIC researchers bred the first mice that completely lacked this protein.
Health & Wellness
High blood pressure, evidence of arterial disease and markers of inflammation in the blood in middle age appear more common in individuals whose parents have Alzheimer's disease than in individuals without a parental history of the condition, according to a report in the November issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Previous twin studies estimate that as much as 60 percent of the risk for Alzheimer's disease is under genetic control, according to background information in the article. Other research has identified several vascular and inflammatory risk factors in midlife that may be associated with the later transition into cognitive decline related to Alzheimer's disease.
Eric van Exel, M.D., Ph.D., of VU University Medical Center, Amsterdam, and colleagues compared some of these vascular and inflammatory factors, such as high blood pressure and levels of pro-inflammatory proteins known as cytokines in the blood, between 206 offspring of 92 families with a history of Alzheimer's disease and 200 offspring of 97 families without a parental history. Researchers measured blood pressure; obtained blood samples to assess genetic characteristics and levels of cholesterol, along with cytokines and other inflammation-related substances; and collected sociodemographic characteristics, medical history and information about diet, exercise and stress levels.
Previous twin studies estimate that as much as 60 percent of the risk for Alzheimer's disease is under genetic control, according to background information in the article. Other research has identified several vascular and inflammatory risk factors in midlife that may be associated with the later transition into cognitive decline related to Alzheimer's disease.
Eric van Exel, M.D., Ph.D., of VU University Medical Center, Amsterdam, and colleagues compared some of these vascular and inflammatory factors, such as high blood pressure and levels of pro-inflammatory proteins known as cytokines in the blood, between 206 offspring of 92 families with a history of Alzheimer's disease and 200 offspring of 97 families without a parental history. Researchers measured blood pressure; obtained blood samples to assess genetic characteristics and levels of cholesterol, along with cytokines and other inflammation-related substances; and collected sociodemographic characteristics, medical history and information about diet, exercise and stress levels.
Malfunctioning circadian clock genes may be responsible for bipolar disorder in children. Researchers writing in the open access journal BMC Psychiatry found four versions of the regulatory gene RORB that were associated with pediatric bipolar disorder.
Alexander Niculescu from Indiana University School of Medicine, Indianapolis, US, worked with a team of researchers at Harvard, UC San Diego, Massachusetts General Hospital and SUNY Upstate Medical University to study the RORA and RORB genes of 152 children with the condition and 140 control children. They found four alterations to the RORB gene that were positively associated with being bipolar. Niculescu said, "Our findings suggest that clock genes in general and RORB in particular may be important candidates for further investigation in the search for the molecular basis of bipolar disorder".
RORB is mainly expressed in the eye, pineal gland and brain. Its expression is known to change as a function of circadian rhythm in some tissues, and mice without the gene exhibit circadian rhythm abnormalities. According to Niculescu, "Bipolar disorder is often characterized by circadian rhythm abnormalities, and this is particularly true among pediatric bipolar patients. Decreased sleep has even been noted as one of the earliest symptoms discriminating children with bipolar disorder from those with attention deficit hyperactivity disorder (ADHD). It will be necessary to verify our association results in other independent samples, and to continue to study the relationship between RORB, other clock genes, and bipolar disorder".
Alexander Niculescu from Indiana University School of Medicine, Indianapolis, US, worked with a team of researchers at Harvard, UC San Diego, Massachusetts General Hospital and SUNY Upstate Medical University to study the RORA and RORB genes of 152 children with the condition and 140 control children. They found four alterations to the RORB gene that were positively associated with being bipolar. Niculescu said, "Our findings suggest that clock genes in general and RORB in particular may be important candidates for further investigation in the search for the molecular basis of bipolar disorder".
RORB is mainly expressed in the eye, pineal gland and brain. Its expression is known to change as a function of circadian rhythm in some tissues, and mice without the gene exhibit circadian rhythm abnormalities. According to Niculescu, "Bipolar disorder is often characterized by circadian rhythm abnormalities, and this is particularly true among pediatric bipolar patients. Decreased sleep has even been noted as one of the earliest symptoms discriminating children with bipolar disorder from those with attention deficit hyperactivity disorder (ADHD). It will be necessary to verify our association results in other independent samples, and to continue to study the relationship between RORB, other clock genes, and bipolar disorder".
Most children actively notice and think about race. A new study has found that children develop an awareness about racial stereotypes early, and that those biases can be damaging.
The study, by researchers at Rush University and Yale University, appears in the November/December 2009 issue of the journal Child Development.
This study looked at more than 120 elementary school children from an ethnically and socioeconomically diverse area of the United States. Children were asked questions to determine their ability to understand another person's stereotypical beliefs as well as their own comprehension of broadly held stereotypes. They were also asked about their own experiences with discrimination. In addition, the children's parents completed questionnaires asking about their parenting.
The study, by researchers at Rush University and Yale University, appears in the November/December 2009 issue of the journal Child Development.
This study looked at more than 120 elementary school children from an ethnically and socioeconomically diverse area of the United States. Children were asked questions to determine their ability to understand another person's stereotypical beliefs as well as their own comprehension of broadly held stereotypes. They were also asked about their own experiences with discrimination. In addition, the children's parents completed questionnaires asking about their parenting.
A new study has found that young people feel differently about two types of parental control, generally viewing a type of control that's thought to be better for their development more positively. However, when parents are very controlling, young people no longer make this distinction and view both types of parental control negatively.
The study, conducted in the United States by researchers at Örebro University in Sweden, appears in the November/December 2009 issue of the journal Child Development. Unlike a lot of prior research on parenting that's focused on control, this study looked at how adolescents view and react to parental control.
Scholars tell us that parental control falls into two categories: behavioral control (when parents help their children regulate themselves and feel competent by providing supervision, setting limits, and establishing rules) and psychological control (when parents are manipulative in their behavior, often resulting in feelings of guilt, rejection, or not being loved). It's thought that behavioral control is better for youngsters' development.
The study, conducted in the United States by researchers at Örebro University in Sweden, appears in the November/December 2009 issue of the journal Child Development. Unlike a lot of prior research on parenting that's focused on control, this study looked at how adolescents view and react to parental control.
Scholars tell us that parental control falls into two categories: behavioral control (when parents help their children regulate themselves and feel competent by providing supervision, setting limits, and establishing rules) and psychological control (when parents are manipulative in their behavior, often resulting in feelings of guilt, rejection, or not being loved). It's thought that behavioral control is better for youngsters' development.
Many parents of preschoolers struggle with their children's fears of real and imaginary creatures. A new study offers some ideas on how they can better manage their children's worries.
The study, which was carried out by researchers at the University of California, Davis, appears in the November/December 2009 issue of the journal Child Development.
Researchers studied about 50 4-, 5-, and 7-year-olds in an effort to identify coping strategies that can be carried out by children. The children listened to a series of short illustrated stories. Each story featured a child alone or with another person who came into contact with something that looked like a real or an imaginary frightening creature, such as a snake or a ghost. Children were asked to predict how intensely afraid each of the children in the stories were, to give a reason why each child felt that way, and to offer a way to help the child in the story feel less afraid.
The study, which was carried out by researchers at the University of California, Davis, appears in the November/December 2009 issue of the journal Child Development.
Researchers studied about 50 4-, 5-, and 7-year-olds in an effort to identify coping strategies that can be carried out by children. The children listened to a series of short illustrated stories. Each story featured a child alone or with another person who came into contact with something that looked like a real or an imaginary frightening creature, such as a snake or a ghost. Children were asked to predict how intensely afraid each of the children in the stories were, to give a reason why each child felt that way, and to offer a way to help the child in the story feel less afraid.
Short-term memory may depend in a surprising way on the ability of newly formed neurons to erase older connections. That's the conclusion of a report in the November 13th issue of the journal Cell, a Cell Press publication, that provides some of the first evidence in mice and rats that new neurons sprouted in the hippocampus cause the decay of short-term fear memories in that brain region, without an overall memory loss.
The researchers led by Kaoru Inokuchi of The University of Toyama in Japan say the discovery shows a more important role than many would have anticipated for the erasure of memories. They propose that the birth of new neurons promotes the gradual loss of memory traces from the hippocampus as those memories are transferred elsewhere in the brain for permanent storage. Although they examined this process only in the context of fear memory, Inokuchi says he "thinks all memories that are initially stored in the hippocampus are influenced by this process."
In effect, the new results suggest that failure of neurogenesis will lead to problems because the brain's short-term memory is literally full. In Inokuchi's words, we may perhaps experience difficulties in acquiring new information because the storage capacity of the hippocampus is "occupied by un-erased old memories."
The researchers led by Kaoru Inokuchi of The University of Toyama in Japan say the discovery shows a more important role than many would have anticipated for the erasure of memories. They propose that the birth of new neurons promotes the gradual loss of memory traces from the hippocampus as those memories are transferred elsewhere in the brain for permanent storage. Although they examined this process only in the context of fear memory, Inokuchi says he "thinks all memories that are initially stored in the hippocampus are influenced by this process."
In effect, the new results suggest that failure of neurogenesis will lead to problems because the brain's short-term memory is literally full. In Inokuchi's words, we may perhaps experience difficulties in acquiring new information because the storage capacity of the hippocampus is "occupied by un-erased old memories."
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This Big Carl from Carl's Jr. boasts twice the meat and twice the cheese as a Big Mac...maybe twice the Firmicutes, too?
This Big Carl from Carl's Jr. boasts twice the meat and twice the cheese as a Big Mac...maybe twice the Firmicutes, too?
A high-fat, high-sugar diet does more than pump calories into your body. It also alters the composition of bacteria in your intestines, making it easier to gain weight and harder to lose it, research in mice suggests. And the changeover can happen in as little as 24 hours, according to a report Wednesday in the new journal Science Translational Medicine.
Many factors play a role in the propensity to gain weight, including genetics, physical activity and the environment, as well as food choices. But a growing body of evidence, much of it accumulated by Dr. Jeffrey I. Gordon of Washington University in St. Louis, shows that bacteria in the gut also play a key role.
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Lauren Johnson, a 12-year-old from Virginia, has been unable to stop sneezing for more than two weeks.
Lauren Johnson, a 12-year-old from Virginia, has been unable to stop sneezing for more than two weeks.
With metronomic regularity, the girl's right arm rises to her face, her hand balled into a fist and partially covered by her sleeve. If Lauren Johnson is talking, she stops when her hand arrives at her nose. Then she sneezes. It's not a big sneeze, but she has to stop to let it out. Then the hand drops and she resumes whatever she was doing. A few seconds later, the action is repeated.
Talk. Sneeze. Play. Sneeze. Sit still. Sneeze. Eat. Sneeze.
As many as 12 times a minute and 12,000 times a day, 12-year-old Lauren sneezes. And there's nothing that six professionals, including doctors, a psychologist and a hypnotist, have been able to do to stop it.
"It gets old after a while," said Lauren. Even that short sentence was bracketed by the sneezes that began on Nov. 1 and haven't stopped since.
New research reveals that children with developmental dyslexia have a deficit in a brain mechanism involved in the perception of speech in a noisy environment. The study, published by Cell Press in the November 12 issue of the journal Neuron, provides the first direct evidence that the human auditory brainstem exhibits remarkable moment-to-moment plasticity and undergoes a fine tuning that is strongly associated with noise exclusion.
Most people have little trouble carrying on a conversation with a friend in a noisy restaurant thanks to the highly adaptive auditory system which manages to focus in on the predictable, repeating pitch of the friend's voice and effectively tune out the random, fluctuating background noise. Although it may be a routine occurrence, exactly how the nervous system manages to accomplish this feat is still a mystery.
"Understanding the relationship between the adaptive auditory system and perception of speech in noise is clinically relevant because recent studies have demonstrated that the 5% of school-age children who are diagnosed with developmental dyslexia can be particularly vulnerable to the deleterious effects of background noise," explains senior study author Dr. Nina Kraus, who directs the Auditory Neuroscience Laboratory at Northwestern University.
Most people have little trouble carrying on a conversation with a friend in a noisy restaurant thanks to the highly adaptive auditory system which manages to focus in on the predictable, repeating pitch of the friend's voice and effectively tune out the random, fluctuating background noise. Although it may be a routine occurrence, exactly how the nervous system manages to accomplish this feat is still a mystery.
"Understanding the relationship between the adaptive auditory system and perception of speech in noise is clinically relevant because recent studies have demonstrated that the 5% of school-age children who are diagnosed with developmental dyslexia can be particularly vulnerable to the deleterious effects of background noise," explains senior study author Dr. Nina Kraus, who directs the Auditory Neuroscience Laboratory at Northwestern University.
