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New Drug-Resistant TB Strains Could Become Widespread, Says New Study

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© University of New South Wales
Chest X-ray image: One in three people already carry the TB bacterium
The emergence of new forms of tuberculosis could swell the proportion of drug-resistant cases globally, a new study has found. The finding raises concern that although TB incidence is falling in many regions, the emergence of antibiotic resistance could see virtually untreatable strains of the disease become widespread.

Australian researchers from the University of New South Wales and the University of Western Sydney have published the new finding in the latest issue of the Proceedings of the National Academy of Sciences.

Laboratory-based studies have suggested that antibiotic-resistant TB strains cause longer-lasting infections but with a lower transmission rate. Therefore, scientists have questioned whether drug-resistant TB strains are more likely than drug-sensitive strains to persist and spread - an important question for predicting the future impact of the disease.

Arrow Down

First case of highly drug-resistant TB found in US

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© AP Photo/David Longstreath
This Oct. 5, 2009 photo shows tuberculosis and HIV patient Vancherleum Maharathanaing, 33, looking out from the isolation ward at Wat Prabat Nampu, in Lopburi, Thailand. Simple TB is simple to treat, a $10 course of medication, but the pills must be taken in specific combinations for six months to completely wipe out the bacteria. If treatment is stopped short, the TB learns to fight back against the drugs, mutating into a tougher strain for which few, if any, medications exist. It can cost $100,000 a year or more to cure drug-resistant TB, which is described as multi-drug-resistant (MDR), extremely drug-resistant (XDR) and completely drug-resistant (CDR).
It started with a cough, an autumn hack that refused to go away.

Then came the fevers. They bathed and chilled the skinny frame of Oswaldo Juarez, a 19-year-old Peruvian visiting to study English. His lungs clattered, his chest tightened and he ached with every gasp. During a wheezing fit at 4 a.m., Juarez felt a warm knot rise from his throat. He ran to the bathroom sink and spewed a mouthful of blood.

I'm dying, he told himself, "because when you cough blood, it's something really bad."

It was really bad, and not just for him.

Doctors say Juarez's incessant hack was a sign of what they have both dreaded and expected for years - this country's first case of a contagious, aggressive, especially drug-resistant form of tuberculosis. The Associated Press learned of his case, which until now has not been made public, as part of a six-month look at the soaring global challenge of drug resistance.

Health

Citrus Surprise: Vitamin C Boosts the Reprogramming of Adult Cells Into Stem Cells

Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, a study published online on December 24th by Cell Press in the journal Cell Stem Cell uncovers an unexpected new role for this natural compound: facilitating the generation of embryonic-like stem cells from adult cells.

Over the past few years, we have learned that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes. Although the reprogrammed cells, called induced pluripotent stem cells (iPSCs), have tremendous potential for regenerative medicine, the conversion is extremely inefficient.

"The low efficiency of the reprogramming process has hampered progress with this technology and is indicative of how little we understand it. Further, this process is most challenging in human cells, raising a significant barrier for producing iPSCs and serious concerns about the quality of the cells that are generated," explains senior study author Dr. Duanqing Pei from the South China Institute for Stem Cell Biology and Regenerative Medicine at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.

Palette

Toxic Burden: Women Put 515 Chemicals on Their Faces Every Day

A study published by Bionsen, a company in the United Kingdom that sells aluminum-free body products, found that the average woman applies 515 chemicals to her face a day. Makeup, perfumes, lotions, mascara, and other beauty products all contribute to the toxic brew that is causing health problems for many women.

The study revealed that the typical woman uses about 13 different beauty products a day. Most of these products contain at least 20 ingredients and additives, many of which can have a detrimental effect on the body and skin. Perfumes alone were found to contain up to 400 different ingredients.

Info

Risk of Suicide and Heart Attacks Goes Up When Men are Told They have Prostate Cancer

Imagine you are a man who has just been told you have a disease that might kill you -- prostate cancer. And the treatment may involve surgery, chemotherapy, radiation and/or hormones that could rob you of your virility, wreck your sex life and even interfere with your ability to urinate. Sound depressing and even terrifying? To some men, this disturbing news may actually be a lot more dangerous than their prostate cancer. A new study just published in PLoS Medicine has found that men newly diagnosed with prostate cancer have an increased risk of cardiovascular events and suicide -- with the youngest men being the most vulnerable.

Researchers from the Karolinska Institute in Stockholm, Sweden, and Harvard University used the Swedish Cancer Register to identify 168,584 men 30 years old or older who were diagnosed with prostate cancer between 1961 and 2004. The research team then turned to Sweden's Causes of Death Register and Inpatient Register to compile information on how many of these men suffered from subsequent fatal or non-fatal cardiovascular events and suicides.

The results showed that prior to 1987, men were approximately 11 times more likely to have a fatal cardiovascular event during the first week after they were told they had prostate cancer than men without the disease.

Arrow Up

Autism has Reached Crisis Proportions

Autism was first brought forth to the public's attention in the 1950's. Since then, it has been rising steadily. The Centers for Disease Control and Prevention has recently released that today 1 in 110 children are autistic. More alarming is the fact that on December 18, 2009, it reported that autism increased by 57% in the last four years.

Most experts attribute the cause of autism to be unknown, defining it as a combination of genetic and environmental factors. However, there has been much controversy as to what, indeed, is responsible for our children not being able to communicate, form relationships, and/or respond to their surroundings.

The most popular of these controversies is vaccines, pointing directly to the Mumps-Measles-Rubella vaccine and the mercury based preservative, thimerosal. Other theories include:
  • Genetics
  • Atypical Brain Development
  • Immune Deficiency Disorder
  • Food Allergies
  • Poor Nutrition
  • Complications During Delivery
  • Environmental Toxins
  • Exposure to Heavy Metals
Experts explain the reason for this dramatic increase with the fact that they are more able to easily diagnose this disorder.

Newspaper

Comedian Dylan Moran: "What Am I Looking Forward To? Incontinence and Memory Loss"

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© PR
"It's attacking boredom, as simple as that" ...Dylan Moran.
Britain's favourite miserabilist comedian sounds off about getting old, religious unbelief and explains how he became a curmudgeonly grump

You've developed a reputation for being a curmudgeonly grump. Aren't you a bit young?

Hang on a minute there, we have to examine this closely. What is the national designated age for the transformation of a well-balanced human being into curmudgeonly grump?

But 38 isn't old, is it?

The thing is, you have to look for a commonality when you're writing about anything and nothing is more universal than lifespan. I'm just playing with the idea of lifespan, my place in it and the resentment that I've left the goodies behind.

Bulb

What's In That? How Food Affects Your Behavior

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Food additives and poor diet could help explain poor school performance, criminal behavior, alcoholism, and the growing numbers of Alzheimer's patients.

According to Dr. Russell Blaylock, high sugar content and starchy carbohydrates lead to excessive insulin release, which in turn leads to falling blood sugar levels, or hypoglycemia. Hypoglycemia causes the brain to secrete glutamate in levels that can cause agitation, depression, anger, anxiety, panic attacks and an increase in suicide risk.

The glutamate that causes this is identical to the flavor-enhancing monosodium glutamate (MSG) and its chemical cousins, which are found in thousands of food products, further exacerbating the problem.

Repeated hypoglycemic episodes increase the risk of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's and ALS (Lou Gehrig's). In children, hypoglycemia often leads to hyperactivity. In both children and adults, it can cause violent and aggressive behavior. In older people, there can be mental confusion.

An anti-hypoglycemic diet would consist of lean meat and lots of fresh vegetables. Another key is limiting sugars and starches.

Sources:

CBN News July 1, 2008

Ambulance

Hard Choice for a Comfortable Death: Sedation

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© Ozier Muhammad/The New York Times
Frank Foster, sleeping under sedation to relieve pain and other effects of liver cancer, at a Long Island hospice unit.
In almost every room people were sleeping, but not like babies. This was not the carefree sleep that would restore them to rise and shine for another day. It was the sleep before - and sometimes until - death.

In some of the rooms in the hospice unit at Franklin Hospital, in Valley Stream on Long Island, the patients were sleeping because their organs were shutting down, the natural process of death by disease. But at least one patient had been rendered unconscious by strong drugs.

The patient, Leo Oltzik, an 88-year-old man with dementia, congestive heart failure and kidney problems, was brought from home by his wife and son, who were distressed to see him agitated, jumping out of bed and ripping off his clothes. Now he was sleeping soundly with his mouth wide open.

Family

Couples Are Better Able to Cope With Health Shocks Than Singles, Study Finds

Marital status plays a significant role in how individuals cope economically with disability and health shocks, according to a working paper by University of British Columbia economists Giovanni Gallipoli and Laura Turner.

In their study, titled "Household Responses to Individual Shocks: Disability and Labour Supply," the researchers examined data from the Canadian Survey of Labour and Income Dynamics (SLID) and found that in marriages, "main-earners" (typically husbands) tend to transfer income and compensate "second-earners" (typically wives). The second-earners, in turn, provide conditional time and care in periods of need (such as illness and disability of main-earner).

The insurance the second-earner provides to the main-earner in the marital contract serves as an important mechanism to help smooth out household income in periods of health and disability shocks to the main-earner; and as a way to support the future earning potential of the main-earner, according to Gallipoli, a UBC economics professor and Turner, now an assistant professor at the University of Toronto. Both Gallipoli and Turner are members of the Canadian Labour Market and Skills Researcher Network.