Epilepsy is a neurological condition where individuals are affected by recurrent seizures that correlate with periods of abnormal brain activity. There are various known causes of epilepsy, such as brain damage or a brain tumour, and these are termed symptomatic epilepsy; however, the majority of cases are termed idiopathic epilepsy, having no known root cause. The idiopathic generalized epilepsies (IGE) account for up to a third of all epilepsies, and epidemiological evidence has suggested that they involve complex genetic contributions (see
previous news). Now a new paper in the journal
Nature Genetics reports an association between microdeletions in a region on chromosome 15 and IGE.
Previous research has suggested that the 15q13-q14 region of chromosome 15 may be involved in epilepsy; susceptibility loci for common IGE syndromes have been mapped to the region, and deletions have been associated with various neuropsychiatric conditions, including epilepsy, autism and schizophrenia. The authors of this new study tested the 15q13.3 region in two independent groups of individuals with IGE and matched controls. The research project was part of
EPICURE, an international collaborative research project to study the genomics and neurobiology of epilepsy, with a view to developing novel therapeutic interventions.
Comment: According to the above article the diagnosed children have severe versions of autism. Such cases, or so it seems, represent only the tip of the iceberg. What is usually overlooked, and this article seems to bring it to our attention, is that probably millions of others share the autistic impairments in a much milder form. This widespread of autistic traits may lead to increase of antisocial behaviours in adulthood. We can only speculate what the real impact of the widespread of autistic impairments on the society is and what is their cause, but the aluminum and mercury included in the vaccines seem to have a causal relationship as described here.