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COVID-19, ACE2, Nicotinic Receptors And The Cholinergic Anti-Inflammatory And Cognitive-Improving Pathway

COVID-19 ACE2
© Getty Images/selvanegra
Graphic representation of COVID-19 binding to the ACE2 receptor on human cells via its spike protein (red)
I've been reading case reports of heart damage in people infected with COVID-19. In fact, someone in my close circle had an episode of fulminant myopericarditis and a strange lung pathology last December, from which he miraculously recovered. I deem SARS-CoV-2 (the virus that causes the disease COVID-19) a likely suspect behind my friend's illness, even though this occurred a few months before the pandemic officially began in Europe.

The following LiveScience article provides some clues as to how both the heart and lungs can be seriously affected during a COVID-19 infection:
The mysterious connection between the coronavirus and the heart

"We're seeing cases of people who don't have an underlying heart disease, who are getting heart damage," said Dr. Erin Michos, the associate director of preventive cardiology at Johns Hopkins School of Medicine. Heart damage isn't typical in mild cases of COVID-19, and tends to occur more often in patients who have severe symptoms and are hospitalized, she said. [...]

Both heart cells and lung cells are covered with surface proteins known as angiotensin-converting enzyme 2 (ACE2) — these molecules serve as "doorways" for the virus to enter cells. But this enzyme is a "double-edged sword," she said. On one hand, the ACE2 molecule acts as a gateway for the virus to enter the cell and replicate, but on the other hand, it normally serves a "protective" function, Michos said.

When tissues in the body are damaged — either by an invading virus such as SARS-CoV-2 or by other means, the body's natural healing response involves releasing inflammatory molecules, such as small proteins called cytokines, into the bloodstream. But paradoxically, too much inflammation can actually make things worse. The ACE2 enzyme acts as an anti-inflammatory, keeping immune cells from inflicting more damage on the body's own cells.

But when the virus latches onto ACE2 proteins, these proteins get knocked out of commission, possibly reducing the anti-inflammatory protection that they give. So the virus may be acting as a double-whammy by damaging cells directly and preventing the body from protecting tissues from inflammatory damage.

"If the heart muscle is inflamed and damaged by the virus, the heart can't function," she said.

The novel coronavirus might also indirectly damage the heart. In this scenario, the patient's immune system winds up "going haywire," Michos said. This scenario has played out in some really sick patients who have highly elevated inflammatory markers — or proteins that signal high levels of inflammation in the body.

This is called a "cytokine storm," Michos said. Cytokine storms damage organs throughout the body, including the heart and liver, she added. It's not clear why some people have such an elevated response compared with others, but some people could be genetically prone to it, she added. [...]

It's really hard to tease out whether having more ACE2 is helpful or harmful, as these proteins are how the virus enters the cells, but also known to protect the cells against injury, Michos said.

Smoking

Bombshell COVID-19 discovery: Smokers are far less likely to contract illness - Scientists 'astonished'


Comment: Holy Geebus, we really are near The End! A British daily has published evidence that smoking tobacco protects people from COVID-19!


smokers outside buildings

Forced into a form of social isolation for the last 20 years, smokers are in fact best positioned to cope with viral pandemics
When world-famous artist wrote a letter to the Daily Mail saying he believes smoking could protect people against the coronavirus many scoffed. Mr Hockney wrote: 'Could it not be that smokers have developed an immune system to this virus? With all these figures coming out, it's beginning to look like that to me.'

Understandably the claim was brushed off as laughable and 'rubbish' by many.

But is it?

A leading infectious disease expert at University College London, Professor Francois Balloux, said there is 'bizarrely strong' evidence it could be true.

Comment: Wow.

It finally happened.

A mainstream article that has no choice but to acknowledge a strong scientific signal that smoking tobacco protects people against certain viruses.

It only took them 20-freaking-years of crappy science and precisely the wrong medical advice - and a farcical 'pandemic' - to figure it out!

Well, we told y'all so.


Health

Stanford University study reveals Covid-19 infection rate far higher than reported, thus virus is FAR LESS LETHAL than believed

blood samples covid-19
© Reuters / Andreas Gebert
Blood samples for a study about the coronavirus disease in Munich, Germany.
A study out of Stanford University tested California residents and found that the Covid-19 infection rate is likely far higher than has been reported, but the virus could also be far less lethal than commonly believed.

Researchers used 3,300 residents in Santa Clara County to conduct their tests, which found that the coronavirus could have infected far more people than has been reported. The study distinguishes itself from past Covid-19 research by using seroprevalence data, meaning the level of a pathogen measured in the blood streams of a specific population.

Titled 'COVID-19 Antibody Seroprevalence in Santa Clara County, California,' the study was published on Friday at MedRxiv, a service that prints health studies before they have been officially peer-reviewed.

The tests found only single-digit percentages when testing for Covid-19 cases, but these "estimates represent a range between 48,000 and 81,000 people infected in Santa Clara County by early April, 50-85-fold more than the number of confirmed cases."

While it may seem like bad news that the virus could be that much more widespread on a global level — which is what the study concludes — it presents several positive factor including the fact that the mortality rate would be much lower than it is now believed, and that many people have symptoms so mild they don't need to seek medical treatment and recover rather quickly.

Comment:


Chart Bar

The 'everyone's got it' theory: We're undercounting COVID cases, but by how much?

Microbiologist
© David Ryder/Reuters
Microbiologist Milagros Sola processes coronavirus tests in a lab at Madigan Army Medical Center at Joint Base Lewis-McChord, Wash., April 14, 2020.
One of the biggest unknowns regarding COVID-19 is how many people get the disease, recover from it, and develop immunity without being captured in our official statistics — perhaps without showing symptoms at all. Some suggest this number could be incredibly high indeed, implying that the disease spreads quickly but has a lower-than-expected fatality rate.

We should have good answers on this soon thanks to "serology" tests, which detect whether someone has antibodies for COVID (meaning they had the virus at some point in the past even if they are not currently infected). But here I'd like to offer a quick overview of what we already know. My own guess is that while we are substantially undercounting cases, it is unlikely that more than, say, 10 percent of the population already has it. Since about two-thirds of the population needs to get it to achieve "herd immunity," that would give us a long way to go if we just lift the lockdowns and hope for the best.


Comment: That's assuming lockdowns even work, and that the costs they incur (monetary AND human) don't overtake the costs of just "hoping for the best". It may be that in the long term, this is just another virus humanity has to pass through. As it is, the mortality rate either similar to, or perhaps 2x, that of the ordinary flu. It's no black death, and certainly won't end up decimating the population. The containment measures however, have a higher chance of doing just that.


To begin, some very simple numbers. At this writing, the U.S. has about 600,000 confirmed cases and a population of about 330 million people. If we are undercounting cases by a factor of ten, that still puts us around 2 percent. To get to 10 percent infected we'd need to be undercounting by a factor of about 50.

Arrow Down

Danish study reveals that coronavirus may be almost 20x less deadly than WHO predicted

denmark doctor
© Reuters / Ritzau Scanpix /Niels Christian Vilmann
A medical worker performs a test for Covid-19 in a new tent extension of Danish National Hospital Rigshospitalet in Copenhagen, Denmark April 2, 2020.
Research on a group of blood donors in Denmark points to its Covid-19 mortality rate being well below one percent of the number of people infected with the disease, according to a team at the Rigshospitalet in Copenhagen.

Tests were carried out on 1,487 samples from Danish blood donors at the hospital showed a mortality rate of just 0.16 percent.


Comment: That puts it in the range of the flu, which has a mortality rate among symptomatic cases of 0.13%. While the mortality rate for symptomatic Covid-19 cases is thus probably higher than 0.16% - say, 0.32% if half of all cases are asymptomatic - it's still an order of magnitude less than what the WHO has been pushing.


That puts the Danish scientists' estimates up to 20 times lower than those of the World Health Organization, which is putting deaths at anywhere between one percent and three percent of the number who contract Covid-19.

The study also suggested that far more Danes than the 5,000 which current figures show have caught the virus, with the number possibly being as high as 400,000.

The test looked for antibodies formed during an infection and found that 22 donors out of the 1,487 were positive, the Danish Broadcasting Corporation reported.

Health

Higher mortality rate in ventilated COVID-19 patients in large sample

ventilator hospital
Mortality could be as high as two thirds among patients with COVID-19 who require ventilation, new data from the United Kingdom's Intensive Care National Audit and Research Center (ICNARC) show.

Some clinicians are asking whether other techniques, such as extracorporeal membrane oxygenation (ECMO), could improve outcomes, but the data are unclear.

The ICNARC data, posted online April 10, include data from 3883 patients with confirmed COVID-19 who were admitted to intensive care units (ICUs) in England, Wales, or Northern Ireland and for whom data on the first 24 hours of ICU care are available.

Comment: See also:


Syringe

Dr. Wodarg warns: 'High-dose Vitamin C & Hydrochloroquine may be WRONG treatments for some COVID-19 patients'

hydroxychloroquine

Hydroxychloroquine as marketed in Europe
A young doctor in an intensive care unit (ICU) in New York made an important observation.

He experienced several patients that did not show any typical symptoms of pneumonia but nevertheless they were extremely breathless (dyspnoeic) and cyanotic (blue skin). "They were not Covid-19 patients; they looked like passengers of an airplane at high-altitude losing pressure."


My warning follows my following observations:

Chloroquine and high-dose intravenous vitamin-C are known to damage the function of erythrocytes in case of a lack of Glucose-6-phosphat-Dehydrogenase (Favism), which is the most frequent enzyme-defect worldwide.

It is inherited and the responsible genes are located on the X-chromosome.

Comment: Here's an extended interview with the NYC doctor (Cameron Kyle-Sidell) who noted that some people being treated for Covid-19 under the assumption that their exposure to SARS-CoV-2 was inducing pneumonia were in fact experiencing an entirely different lung disorder:

'Patients need oxygen, not pressure!' New York city physician finds 'Covid-19 patients' is akin to high-altitude sickness, NOT pneumonia

It should be pointed out that the French expert who first drew attention to the efficacy of hydrochloroquine in COVID-19 patients - Professor Didier Raoult - has said since the outset that it is NOT to be used on patients who have worsened to a critical condition.


SOTT Logo Radio

Objective:Health - Bill Gates: Philanthropist, World Savior, AntiChrist

O:H header
When exactly did we start listening to Bill Gates about anything? Anything other than computer stuff, that is. Lately Bill Gates has been showing up on various platforms in various interviews telling everyone they can't leave their homes until there's a vaccine for the coronavirus. And who exactly put Bill in charge? Why is he acting like he's calling the shots? Why is the IT guy giving us medical directives?

In this episode of Objective:Health we take a deep dive into the agenda of William Henry Gates III, and the results are downright creepy. Bill Gates is a driven, power-hungry, megalomaniac with a strong fetish for vaccines and extreme forms of surveillance, not to mention creating technologies that move the human race closer and closer to a kind of technological slavery. Oh, and he has a depopulation agenda. The scariest thing is, despite never being elected to any political position, he manages to push through his agenda by wielding his massive wealth. So, no thanks Bill, we don't want your crappy vaccines and ID chips.

Join us on this episode of Objective:Health for some good ol' fashion Bill bashin'. Send Bill back to the IT department. Nobody wants him ruling the world.


And check us out on Brighteon!


Running Time: 00:57:05

Download: MP3 — 52.3 MB


Life Preserver

Back to basics: Best alternatives for self-care against viral infections

dieta cetogénica
The global spread of coronavirus/COVID-19 has sent researchers and scientists into overdrive to find both treatments and cures.

In the meantime, doctors and other practitioners are, to a large extent, improvising. They are employing best-care practices for the very sick in hospital and providing best-guess advice for those with mild symptoms who are self-isolating, and for those who have no symptoms and would like to keep it that way.

It's important to remember that there are no proven treatments for coronavirus. The picture changes daily. But right now, the main treatment for severe cases is not a drug at all but supportive care and oxygen therapy, administered via ventilators in order to help people breathe.


Comment: Unfortunately ventilators may be killing more people than they are saving!


Some doctors are giving standard antibiotics to prevent or treat secondary infections. A few are trying experimental drugs, like the novel antiviral Remdesivir, not yet approved for widespread use.

Others are using "off label" treatments — drugs or drug combinations not originally intended for the treatment of coronavirus, such as chloroquine with or without hydroxychloroquine (both are anti-malaria drugs) or the antibiotic Zithromax. Just this week, the U.S. Food & Drug Administration authorized the use of anti-malaria drugs to treat coronavirus, stating that the benefit outweighs the risks, despite emerging reports of problems with both the drugs, especially worryingly high heart rates and stories of hydroxychloroquine poisonings in the U.S. and Africa following an ill-advised tweet by President Trump.

Results from short-term trials for other drugs are starting to come in, but so far none are very encouraging.

Comment: See also:


Attention

Mike Whitney: Are ventilators killing more people than they're saving?

ventilators
"Researchers in Wuhan...reported that, of 37 critically ill Covid-19 patients who were put on mechanical ventilators, 30 died within a month. In a U.S. study of patients in Seattle, only one of the seven patients older than 70 who were put on a ventilator survived; just 36% of those younger than 70 did." ("With ventilators running out, doctors say the machines are overused for Covid-19", STAT News)
Think about that for a minute. What these figures mean is that, if you're over 70 and you're put on a ventilator because you have coronavirus, you're probably going to die. More importantly, it means that it was probably the ventilator that killed you. Isn't that something the public ought to know?

I think it is.

"One in seven" is very poor odds. They aren't the odds a rational person would bet his life on unless he had a death wish or a very serious gambling problem. So what's going on here, and why is there so much misleading blabber about ventilators?

Comment: We already know the mortality rate for COVID-19 has been drastically manipulated. Now we are seeing that a large portion of those who are dying might be from the most popular treatment being used to fight it! The media has been up in arms over the use of hydroxychloroquine, but their attention would be better directed at the widespread use of ventilators.

For more information see: