
This cross-section of the hippocampus shows island cells (green) projecting to the CA1 region of the hippocampus.
MIT neuroscientists have now discovered how two neural circuits in the brain work together to control the formation of such time-linked memories. This is a critical ability that helps the brain to determine when it needs to take action to defend against a potential threat, says Susumu Tonegawa, the Picower Professor of Biology and Neuroscience and senior author of a paper describing the findings in the Jan. 23 issue of Science.
"It's important for us to be able to associate things that happen with some temporal gap," says Tonegawa, who is a member of MIT's Picower Institute for Learning and Memory. "For animals it is very useful to know what events they should associate, and what not to associate."
The interaction of these two circuits allows the brain to maintain a balance between becoming too easily paralyzed with fear and being too careless, which could result in being caught off guard by a predator or other threat.
The paper's lead authors are Picower Institute postdocs Takashi Kitamura and Michele Pignatelli.














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