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Scientists restore rejects through cross-circulation to a pig

Human Lung
© Ahmed Hozain and John O'Neill/Columbia Engineering
A human lung that failed on EVLP (left) and then recovered on cross-circulation (right).
Damaged human lungs could be made suitable for use in transplants through cross-circulation to a pig, new research suggests.

In a paper in the journal Nature Medicine, a team from Vanderbilt and Columbia universities in the US describes trials which showed substantial improvements of cell viability, tissue quality, inflammatory responses and respiratory function using the technique.

Transplantation is the only definitive cure for end-stage lung disease, but its use is limited by an insufficient supply of high-quality donor lungs.

Only about 20% are considered to be in suitable condition, says Vanderbilt's Matthew Bacchetta, making lungs the least-used solid organ for transplant

The current standard of care for donor lungs is ex vivo lung perfusion (EVLP), a mechanical support system that can preserve lungs for up to eight hours but has limited means to rehabilitate them.

In previous work, Bacchetta, Columbia's Gordana Vunjak-Novakovic and colleagues found that damaged pig lungs could be reconditioned when connected to the circulation system of another pig.

Rose

Tomato plants send electrical signals to each other through fungi

tomato
© University of Alabama in Huntsville
Dr. Yuri Shtessel and Dr. Alexander Volkov studied electrical signal propagation between tomato plants.
The soil beneath our feet is alive with electrical signals being sent from one plant to another, according to research in which a University of Alabama in Huntsville (UAH) distinguished professor emeritus in the Department of Electrical and Computer Engineering participated.

UAH's Dr. Yuri Shtessel and Dr. Alexander Volkov, a professor of biochemistry at Oakwood University, coauthored a paper that used physical experiments and mathematical modeling to study transmission of electrical signals between tomato plants.

Dr. Shtessel's specialty is control engineering. Control algorithms are widely applicable across disciplines, for instance in aerospace vehicle control.

Comment: It's no wonder our food supply is in danger when modern agricultural techniques break up the soil through tillage and kill fungi - and many other forms of life - through pesticides, herbicides and unsuitable fertilizers:


Cassiopaea

Enormous 'superflare' detected on nearby star

flares
© National Astronomical Observatory of Japan
Observing the stellar flares on AD Leonis 16 light years away. Its lower temperature makes it a prime target to study flares and the more explosive 'superflare'.
The cold, dark chaos of space is filled with mystery.

Fortunately, the ways in which we can peer into the mists of the void are increasing, and now include Kyoto University's 3.8 meter Seimei telescope.

Using this new instrument -- located on a hilltop in Okayama to the west of Kyoto -- astronomers from Kyoto University's Graduate School of Science and the National Astronomical Observatory of Japan have succeeded in detecting 12 stellar flare phenomena on AD Leonis, a red dwarf 16 light years away. In particular, one of these flares was 20 times larger than those emitted by our own sun.

"Solar flares are sudden explosions that emanate from the surfaces of stars, including our own sun," explains first author Kosuke Namekata.

Comment: See also: And check out SOTT radio's:


Moon

Researchers determine a younger age for Earth's moon

birth of moon
© Ron Miller
The moon is born
The moon formed a little later than previously assumed. When a Mars-sized protoplanet was destroyed in a collision with the young Earth, a new body was created from the debris ejected during this collision, which became the moon. Planetary geophysicists at the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt; DLR), led by Maxime Maurice, together with researchers at the University of Münster, have used a new numerical model to reconstruct the time at which the event occurred — 4.425 billion years ago. The previous assumptions about the formation of the moon were based on an age of 4.51 billion years — that, is 85 million years earlier than the new calculations reveal. The scientists have reported their findings in Science Advances.

Galaxy

Uncovering the hidden magnetic universe

magnetic fields universe
© Pauline Voß for Quanta Magazine
Hidden magnetic field lines stretch millions of light years across the universe.
Astronomers are discovering that magnetic fields permeate much of the cosmos. If these fields date back to the Big Bang, they could solve a major cosmological mystery.

Anytime astronomers figure out a new way of looking for magnetic fields in ever more remote regions of the cosmos, inexplicably, they find them.

These force fields — the same entities that emanate from fridge magnets — surround Earth, the sun and all galaxies. Twenty years ago, astronomers started to detect magnetism permeating entire galaxy clusters, including the space between one galaxy and the next. Invisible field lines swoop through intergalactic space like the grooves of a fingerprint.

Last year, astronomers finally managed to examine a far sparser region of space — the expanse between galaxy clusters. There, they discovered the largest magnetic field yet: 10 million light-years of magnetized space spanning the entire length of this "filament" of the cosmic web. A second magnetized filament has already been spotted elsewhere in the cosmos by means of the same techniques. "We are just looking at the tip of the iceberg, probably," said Federica Govoni of the National Institute for Astrophysics in Cagliari, Italy, who led the first detection.

The question is: Where did these enormous magnetic fields come from?

Microscope 1

In cell death, a stunning display of Intelligent Design

cell death
Some counselors try to comfort the grieving by saying that "dying is a part of life," as if that would cheer up someone dealing with the loss of a loved one. Because of our exceptional natures, people have thoughts of the soul, eternity, and love. These far outstrip the physical necessity of disposing of a body that was housing a sentient being a short time ago. Cells only have the physical disposal to contend with, so in the following discussion, one must not draw comparisons too tightly between human death and cell death.

To a cell, dying really is a part of life. There's nothing to grieve about! In fact, billions of cells die in the process of embryonic development, as our organs, fingers, and tissues are sculpted. That's a wonderful thing. Nevertheless, tissues face real challenges in all stages of cell death, from deciding what cells need to bow out, to disposing of the "corpses" afterward. The cellular morgue is exquisitely designed for the challenge.

Sun

New super white paint reflects up to 98% of the Sun's heat

greece white houses

Whereas traditional white paints typically reflect around 85% of solar radiation to help keep buildings cool, a new "super white" paint can reflect up to 98%
Just like a tennis player might don a white shirt instead of a black one on warm summer's day, researchers see great potential in dressing buildings in reflective white paints to keep them cool. A team of material scientists is reporting a major advance in this area, producing a new kind of super white paint that reflects almost all incoming radiation from Sun.

For some time, scientists have been exploring how broad use of white paint could significantly cool buildings, and even the surrounding microclimate. One NASA study from 2012, for example, found that white coatings could reduce peak rooftop temperatures in New York City by an average of 43 °F (24 °C).

While researchers continue to probe the possibilities in this area, with some even producing reflective paint made from glass, the best performing white paints on the market reflect about 85 percent of solar radiation, while absorbing the rest. The team from the University of California, Los Angeles (UCLA) hoped to improve on this by making a few tweaks to the recipe.

Comment: See also:


Cut

New gene editing tool to correct mutations in mitochondrial DNA

mitochondria
© Unknown
Mitochondria
An enzyme pulled from toxic bacteria can enter the organelle and perform single-nucleotide DNA swaps.

In a creative feat of molecular engineering, scientists have for the first time developed a gene editing tool capable of making targeted, single base pair changes in the DNA of mitochondria. The new editor, derived from a bacterial toxin, could allow researchers to better study mitochondrial diseases ahead of possible future treatments, Science reports.

While genome editing tools such as CRISPR can easily enter the nucleus of a cell, the mitochondria are swathed in membranes, making them inaccessible to bulky CRISPR molecules. Other tools such as TALENs and ZFNs have previously passed into the mitochondria of plant and animal cells, but STAT reports that these early tools were only able to cut out and remove mutated DNA, not correct it with targeted precision. Because of the difficulty in rewriting mitochondrial DNA, scientists have struggled to create animal models of mitochondrial diseases with the same mutations to study them in detail.

Fyodor Urnov, a biologist at the Innovative Genomics Institute, who reviewed the team's July 8 paper in Nature, tells STAT.
"We've been looking for a technology like this for a very long time. We've been able to make point mutations in human nuclear DNA for 15 years, but mitochondria have resisted that furiously, much to the great frustration of everybody. With this technology, mitochondrial research will enter a golden age."

Black Cat 2

People along Silk Road kept cats as pets 1,000 years ago

Maine Coon
© DenisNata / Stock Adobe.com
Common domestic cats, as we know them today, might have accompanied Kazakh pastoralists as pets more than 1,000 years ago.

This has been indicated by new analyses done on an almost complete cat skeleton found during an excavation along the former Silk Road in southern Kazakhstan. An international research team led by Martin Luther University Halle-Wittenberg (MLU), Korkyt-Ata Kyzylorda State University in Kazakhstan, the University of Tübingen and the Higher School of Economics in Russia has reconstructed the cat's life, revealing astonishing insights into the relationship between humans and pets at the time. The study will appear in the journal "Scientific Reports".

The tomcat - which was examined by a team led by Dr Ashleigh Haruda from the Central Natural Science Collections at MLU - did not have an easy life. "The cat suffered several broken bones during its lifetime," says Haruda. And yet, based on a very conservative estimate, the animal had most likely made it past its first year of life. For Haruda and her colleagues, this is a clear indication that people had taken care of this cat.

During a research stay in Kazakhstan, the scientist examined the findings of an excavation in Dzhankent, an early medieval settlement in the south of the country which had been mainly populated by the Oghuz, a pastoralist Turkic tribe. There she discovered a very well-preserved skeleton of a cat. According to Haruda, this is quite rare because normally only individual bones of an animal are found during an excavation, which prevents any systematic conclusions from being drawn about the animal's life. The situation is different when it comes to humans since usually whole skeletons are found. "A human skeleton is like a biography of that person. The bones provide a great deal of information about how the person lived and what they experienced," says Haruda. In this case, however, the researchers got lucky: after its death, the tomcat was apparently buried and therefore the entire skull including its lower jaw, parts of its upper body, legs and four vertebrae had been preserved.

Galaxy

Astronomers discover South Pole Wall, a gigantic structure stretching 1.4 billion light-years across

South Pole Wall
© D. Pomarede, R. B. Tully, R. Graziani, H. Courtois, Y. Hoffman, J. Lezmy
A visualization showing the South Pole Wall, a large cluster of galaxies near the southernmost part of the sky.
Spectacular 3D maps of the universe have revealed one of the biggest cosmic structures ever found — an almost-inconceivable wall stretching 1.4 billion light-years across that contains hundreds of thousands of galaxies.

The South Pole Wall, as it's been dubbed, has been hiding in plain sight, remaining undetected until now because large parts of it sit half a billion light-years away behind the bright Milky Way galaxy. The South Pole Wall rivals in size the Sloan Great Wall, the sixth largest cosmic structure discovered. (One light-year is roughly 6 trillion miles, or 9 trillion kilometers, so this "biggest cosmic structure" is mind-bendingly humongous.)

Astronomers have long noticed that galaxies are not scattered randomly throughout the universe but rather clump together in what's known as the cosmic web, enormous strands of hydrogen gas in which galaxies are strung like pearls on a necklace that surround gigantic and largely empty voids.