
Scanning electron micrograph of a microsporidian spore with an extruded polar tubule inserted into a eukaryotic cell. The spore injects the infective sporoplasms through its polar tubule.
The findings could help develop effective treatments against these common global pathogens and may help explain their most virulent attacks.
"Microsporidian infections are hard to treat because until now we haven't known a lot about this common pathogen," says Soo Chan Lee, Ph.D., lead author and a postdoctoral researcher in the Duke Department of Molecular Genetics and Microbiology. "Up to 50 percent of AIDS patients have microsporidial infections and develop chronic diarrhea. These infections are also detected in patients with traveler's diarrhea, and also in children, organ transplant recipients and the elderly."









