
© Karin Higgins/UC Davis photoProf. Kent Lloyd, director of the UC Davis Mouse Biology Program, in the lab. Gene-edited and “knockout” mice have become a vital tool in biomedical research.
An international team of researchers has identified a cause for chronic bad breath (halitosis), with the help of gene knockout mice from the
UC Davis Mouse Biology Program. The results are published Dec. 18 in the journal
Nature Genetics.
While most cases of bad breath are linked bacteria growing in the mouth,
up to 3 percent of the population have chronic halitosis of no obvious cause."It's important to identify the cause of persistent halitosis, and differentiate that cause from relatively benign causes (e.g., gum disease) and the more morbid causes such as liver cirrhosis," said Professor Kent Lloyd, director of the Mouse Biology Program at UC Davis.
Researchers at
Radboud University in The Netherlands have been studying families with chronic bad breath for several years.
They found that these people produced a lot of sulfur-based compounds in their breath, especially methanethiol which has an unpleasant boiled-cabbage smell. Methanethiol is normally produced during digestion but broken down in the body.
Some bacteria can break down sulfur compounds. Based on bacterial genes, the team identified a human protein, selenium binding protein 1, which can convert methanethiol into other and compounds.
Comment: The good doctors are on the right track.