Science & Technology
Apparently bored with the blasé above-ground digs available all over the city, a Deep Ocean Technology is making your submarine dreams a reality with "Discus," a resort for people who prefer look at some lush ocean life over a crowded cityscape. When construction is completed, Discus will feature a large, above-water disc - complete with a helipad, of course - where visitors can enjoy food, drink, and any other pleasure money can buy. Then, when night falls, guests can retreat down to the massive underwater portion of the resort where the extravagant suites reside.
Published in Science, CMU's Alex John London, and McGill's Jonathan Kimmelman and Benjamin Carlisle argue that current research ethics frameworks do not flag drug trials that, while not putting patients at risk, produce biased evidence. As an example, they point to phase IV research -- when pharmaceutical companies test drugs and devices that have been approved for marketing. They insist that without an adequate system of checks in place, phase IV trials will continue to be used by drug companies to market products without generating the information that clinicians and policy makers can use to improve care and maintain a more cost-effective health system.
"Medical care isn't like most consumer products where the consumer can assess the quality of the product from its performance and estimate its value for the money," said London, associate professor of philosophy and director of CMU's Center for Ethics and Policy. "In medicine we are forced to rely on what can at times be complex scientific studies for this information. So it is difficult to overstate the importance of preserving the integrity of this research."

A team led by Scripps Research Institute scientists has found evidence that, as humans evolved, an extra copy of a brain-development gene allowed neurons to migrate farther and develop more connections.
What genetic changes account for the vast behavioral differences between humans and other primates? Researchers so far have catalogued only a few, but now it seems that they can add a big one to the list. A team led by scientists at The Scripps Research Institute has shown that an extra copy of a brain-development gene, which appeared in our ancestors' genomes about 2.4 million years ago, allowed maturing neurons to migrate farther and develop more connections.
Surprisingly, the added copy doesn't augment the function of the original gene, SRGAP2, which makes neurons sprout connections to neighboring cells. Instead it interferes with that original function, effectively giving neurons more time to wire themselves into a bigger brain.
Venus will take about six hours to complete its transit, appearing as a small black dot on the sun's surface, in an event that will not happen again until 2117.
Jay M. Pasachoff, astronomer at Williams College, Massachusetts, US, explores the science behind Venus' transit and gives an account of its fascinating history, the journal Physics World reports.
Transits of Venus occur only on very rare occasions when Venus and the Earth are in a line with the Sun. At other times, Venus passes below or above the Sun because the two orbits are at a slight angle to each other, according to a Williams statement.
Transits occur in pairs separated by eight years, with the gap between pairs of transits alternating between 105.5 and 121.5 years - the last transit was in 2004.
Building on the original theories of Copernicus from 1543, scientists were able to predict and record the transits of both Mercury and Venus in the centuries that followed.
Kepler successfully predicted that both planets would transit the Sun in 1631, part of which was verified with Mercury's transit of that year. But the first transit of Venus to actually be viewed was in 1639 - an event that had been predicted by the English astronomer Jeremiah Horrocks.
Taking a slight jab at other popular videoconferencing options, Dr. Vertegaal said, "Why Skype when you can talk to a life-size 3D holographic image of another person?"
Dr. Vertegaal and his team are calling this new technology "TeleHuman," and it very much resembles the famous holodeck from Star Trek. In order to speak with one another, 2 people stand in front of long, life-sized cylindrical tubes. These tubes not only display a 3D image of the other person, but also capture 3D video. Projectors on the inside create a 3D image to display on the outside of the tube while cameras and tracking technology, such as the Kinect sensors, convert the data into another 3D image.
Since the pods are fitted to collect 3D data, those using TeleHuman are able to see 360 degree images and can even walk around a TeleHuman pod to see the other person's side or back.
Dr. Vertegaal said he and his team were able to assemble the devices mostly using existing hardware, like a 3D projector, convex mirrors and of course, the life-sized acrylic tubes.
But new images returned from NASA's Lunar Reconnaissance Orbiter suggest that our natural satellite isn't dead at all. It's actually pretty active, having both shrank and grown fairly recently in its history.
The first evidence of an active moon came in 2010 when LRO's camera returned high-resolution pictures of landforms called lobate scarps. Previously found only in the equatorial regions in images from Apollo missions 15, 16 and 17, these lobe-shaped cliffs have now been found scattered across the lunar surface.
"Drive-by attacks" in which hackers booby-trap legitimate websites with malicious code continue to be a bane, the US-based anti-virus vendor Symantec said in its Internet Security Threat Report.
Websites with religious or ideological themes were found to have triple the average number of "threats" that those featuring adult content, according to Symantec.
"It is interesting to note that websites hosting adult/pornographic content are not in the top five, but ranked tenth," Symantec said in the report.
"We hypothesize that this is because pornographic website owners already make money from the Internet and, as a result, have a vested interest in keeping their sites malware-free; it's not good for repeat business."

After a DNA molecules breaks, the broken ends search for an intact DNA region with the same sequence in order to get repaired. The image shows an artist impression of the contact point between a RecA-protein DNA molecule (the ‘broken end’; horizontal) and a DNA molecule (vertical), where it is probed whether both molecules have the same sequence. If they do not, they will break the contact. If the same sequence is found however, the molecules stably bind and the repair process is initiated. The present study discovered the mechanism of the recognition process from dual molecule experiments where individual DNA molecules can be manipulated with beads.
Using a smart new dual-molecule technique, the Delft group has now found out how the DNA molecule is able to perform this search and recognition process in such an efficient way. This week, the researchers report their findings in Molecular Cell.
A staggering problem
Sometimes, the DNA double helix gets broken: both strands are accidentally cut. This presents a vital problem because cells cannot cope with such damaged DNA.
Genomic DNA instabilities such as these, are a known cause of cancer. The good news is that an intricate DNA repair system exists which is impressively error-proof and efficient. How does this work?
First, proteins form a filamentous structure on the broken DNA end. Second, this filament examines recently copied DNA or the second DNA chromosome (remember that we have two copies of each chromosome) in search of a DNA sequence that matches that of the broken end.
Note that this is a daunting task: given that, for example, our human genome contains three billion base pairs, finding your few hundred base pairs of interest, is really like finding a needle in a haystack.
'Still this search process occurs within minutes and with great efficiency. How that is achieved, has been a mystery for decades.
The new experiments from our group now resolve this by revealing the key step in the process, the molecular recognition step', says scientist Iwijn de Vlaminck, who was the postdoc that did the experiments in the group of Prof. Cees Dekker at Delft.

As lightning flashes, it creates low frequency waves that circle Earth, a phenomenon known as Schumann Resonance, which tells scientists what kinds of atoms exist in a planet's atmosphere.
This electromagnetic signature, known as Schumann Resonance, had only been observed from Earth's surface until, in 2011, scientists discovered they could also detect it using NASA's Vector Electric Field Instrument (VEFI) aboard the U.S. Air Force's Communications/Navigation Outage Forecast System (C/NOFS) satellite.
In a paper published on May 1 in The Astrophysical Journal, researchers describe how this new technique could be used to study other planets in the solar system as well, and even shed light on how the solar system formed.
"The frequency of Schumann Resonance depends not only on the size of the planet but on what kinds of atoms and molecules exist in the atmosphere because they change the electrical conductivity," says Fernando Simoes, the first author on this paper and a space scientist at NASA's Goddard Space Flight Center in Greenbelt, Md. "So we could use this technique remotely, say from about 600 miles above a planet's surface, to look at how much water, methane and ammonia is there."
But scientists are still unable to make predictions precise enough for people to plan how to handle the loss of land and threat to coastal communities expected over this century, two researchers point out in a commentary this week in the May 4 issue of the journal Science.
"We know sea level is going to rise, but how much, and how fast, and where, we really still don't know," co-author Josh Willis, a climate scientist at NASA's Jet Propulsion Laboratory, told LiveScience.
The complex seas
It turns out the ocean isn't like water in a bathtub; it doesn't rise uniformly as more water pours in. As global warming raises sea levels, some places are expected to see higher-than-average increases, and a few places may even see decreases.
Currently, projections suggest that over the course of this century, sea levels will rise between 8 inches and 6.6 feet (20 centimeters and 2 meters) around the planet. Scientists know this increase will be driven by the expansion of water as it warms (warmer water takes up more space) and the melting of ice, most importantly, ice stored in the massive ice sheets that cover Greenland and Antarctica.











