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Powerful algorithms can 'predict' the biological language of cancer and Alzheimer's

algorithm cancer alzheimer's
Powerful algorithms used by Netflix, Amazon and Facebook can 'predict' the biological language of cancer and neurodegenerative diseases like Alzheimer's, scientists have found.

Big data produced during decades of research was fed into a computer language model to see if artificial intelligence can make more advanced discoveries than humans.

Academics based at St John's College, University of Cambridge, found the machine-learning technology could decipher the 'biological language' of cancer, Alzheimer's, and other neurodegenerative diseases.

Comment: See also:


Comet 2

Study finds over 5,000 tons of extraterrestrial dust fall to Earth each year

Electron micrograph Concordia micrometeorite
© Cécile Engrand/Jean Duprat
Electron micrograph of a Concordia micrometeorite extracted from Antarctic snow at Dome C.
Every year, our planet encounters dust from comets and asteroids. These interplanetary dust particles pass through our atmosphere and give rise to shooting stars. Some of them reach the ground in the form of micrometeorites.

An international program conducted for nearly 20 years by scientists from the CNRS, the Université Paris-Saclay and the National museum of natural history with the support of the French polar institute, has determined that 5,200 tons per year of these micrometeorites reach the ground. The study will be available in the journal Earth & Planetary Science Letters from April 15.

Micrometeorites have always fallen on our planet. These interplanetary dust particles from comets or asteroids are particles of a few tenths to hundredths of a millimeter that have passed through the atmosphere and reached the Earth's surface.

Comment:


Pi

First results from Fermilab's Muon g-2 experiment strengthen evidence of new physics

muon g-2 ring
© Reidar Hahn, Fermilab
The Muon g-2 ring sits in its detector hall amidst electronics racks, the muon beamline, and other equipment. This impressive experiment operates at negative 450 degrees Fahrenheit and studies the precession (or wobble) of muons as they travel through the magnetic field.
Combined results from Fermilab and Brookhaven show strong evidence that our best theoretical model of the subatomic world is incomplete.

The long-awaited first results from the Muon g-2 experiment at the U.S. Department of Energy's Fermi National Accelerator Laboratory show fundamental particles called muons behaving in a way that is not predicted by scientists' best theory, the Standard Model of particle physics. This landmark result, made with unprecedented precision, confirms a discrepancy that has been gnawing at researchers for decades.

The strong evidence that muons deviate from the Standard Model calculation might hint at exciting new physics. Muons act as a window into the subatomic world and could be interacting with yet undiscovered particles or forces.

Comment: See also:


Comet 2

New Comet C/2019 U5 (PANSTARRS)

CBET 4953 & MPEC 2021-G80, issued on 2021, April 07, announce that an apparently asteroidal object (magnitude ~21.0) discovered on CCD images obtained with the F51 Pan-STARRS 1 survey's 1.8m Ritchey-Chretien on 2019, October 22.22 and designated A/2019 U5 (cf. MPEC 2019-V10) has been found to show cometary appearance by other CCD observers over the past half year. The new comet has been designated C/2019 U5 (PANSTARRS).

Stacking of 20 unfiltered exposures, 120 seconds each, obtained remotely on 2021, April 02.1 from Z08 (Telescope Live, Oria) through a 0.7 m f/8 Ritchey Chretien + CCD, shows that this object is a comet with a compact coma about 15" arcsec in diameter (Observers E. Guido, M. Rocchetto, E. Bryssinck, M. Fulle, G. Milani, C. Nassef, G. Savini, A. Valvasori).

Our confirmation image (click on it for a bigger version; made with TYCHO software by D. Parrott)

Comet C/2019 U5 (PANSTARRS)
© Remanzacco Blogspot

Attention

Possible nova detected in Sagittarius

Following the posting on the Central Bureau's Transient Object Confirmation Page about a possible Nova in Sgr (TOCP Designation: PNV J17581670-2914490) we performed some follow-up of this object through a TEL 0.6-m f/6.5 astrograph + CCD located in the El Sauce Observatory in Chile and operated by Telescope Live network (MPC Code X02).

This transient has been discovered by Andrew Pearce at 8.4 mag (unfiltered) on 2021-04-04.825 UT using a Canon 1100D DSLR camera with a 100mm f/2.8 lens. Total exposure time was 20 seconds (2 x 10s images stacked). Rob McNaught reported non-detection on 2021-04-02.776 UT (unfiltered limiting mag 11.0).

On images taken on April 06.40, 2021 we can confirm the presence of an optical counterpart with B-filtered CCD magnitude +8.955 (R-filtered & V-filtered images were saturated in 5-second exposures) at coordinates:

R.A. = 17 58 16.08, Decl.= -29 14 56.4

(equinox 2000.0; Gaia DR2 catalogue reference stars for the astrometry).

Our confirmation image (click on it for a bigger version):
NOVA SAGITTARII 2021 No. 2
© Remanzacco Blogspot

Microscope 1

Genome analysis reveals unknown ancient human migration into Europe

bacho kiro cave excavation neanderthals
© Nikolay Doychinov/AFP via Getty Images
The Bacho Kiro cave in Bulgaria. The research is based on analysis of several ancient human remains – including a whole tooth and bone fragments – found in a cave in Bulgaria last year.
Genetic sequencing of human remains dating back 45,000 years has revealed a previously unknown migration into Europe and showed intermixing with Neanderthals in that period was more common than previously thought.

The research is based on analysis of several ancient human remains - including a whole tooth and bone fragments - found in a cave in Bulgaria last year.

Genetic sequencing found the remains came from individuals who were more closely linked to present-day populations in east Asia and the Americas than populations in Europe.

Comment: Bacho Kiro has proved to be a treasure chest of prehistoric information:

Humans were in Europe earlier and had cultural interactions with Neanderthals, new fossil finds in Bulgaria reveal


Microscope 2

Researchers can now collect and sequence DNA from the air

dna strand
© Shutterstock
We leave DNA all over the place, including in the air, and for the first time, researchers have collected animal DNA from mere air samples, according to a new study.

The DNA that living things, human and otherwise, shed into the environment is called environmental DNA (eDNA). Collecting eDNA from water to learn about the species living there has become fairly common, but until now, no one had attempted to collect animal eDNA from the air.

"What we wanted to know was whether we could filter eDNA from the air to track the presence of terrestrial animals," study author Elizabeth Clare, an ecologist at Queen Mary University of London, said in a video abstract for the study, published Mar. 31 in the journal PeerJ. "We were interested in whether we could use this 'airDNA' as a way to assess what species were present in a burrow or a cave where we could not easily see or capture them," she added.

As a proof-of-concept experiment, Clare and her colleagues tried collecting DNA from the air in an animal facility housing a model organism, the naked mole rat. The researchers detected both human and mole rat DNA in air from both the mole rat enclosures and the room where the enclosures are housed.

Info

High-energy particle accelerators within our galaxy discovered

Move over, CERN. Unknown sources in the Milky Way dubbed "PeVatrons" accelerate protons to energies of a few peta-electronvolts - dozens of times higher than the yield of the Large Hadron Collider. Now, new data from a high-altitude experiment in Tibet confirm that such very-high-energy cosmic rays are indeed produced in our own galaxy.
Ultra high-energy rays
© APS; Background (atomic hydrogen distribution): HEASARC / LAMBDA / NASA / GFSC
Ultra high-energy diffuse gamma rays (yellow points) are distributed along the Milky Way Galaxy. The gray shaded area indicates the area outside the detectors' field of view.
"The results paint a much fuller picture of the PeVatron population in the Milky Way," says Pat Harding (Los Alamos National Laboratory), who was not involved in the study.

The distribution of cosmic rays by energy suggests these particles come in two varieties. The most extreme ultra-high-energy cosmic rays (UHECRs) are believed to come from remote galaxies (see the May 2021 issue of Sky & Telescope to learn more about these harbingers). But the majority of cosmic rays, with energies below 4 PeV, are thought to originate in the Milky Way. However, the true nature of the PeVatron particle accelerators has remained unknown, largely because the paths of cosmic rays are bent by galactic magnetic fields, so they do not "point back" to their origin.

A large team of Chinese and Japanese scientists known as the Tibet ASγ Collaboration has now detected a few dozen very-high-energy (VHE) gamma rays from the Milky Way that aren't associated with known sources. These gamma rays, collected between 2014 and 2017, are thought to be produced when cosmic rays slam into atomic nuclei in the interstellar medium. Theory says they carry about 10% of the original cosmic-ray energy. The most energetic one detected by the Tibet ASγ team packs a punch of 0.957 PeV - an all-time record.

Rose

Fungi manipulate bacteria to enrich soil with nutrients

hyphae
© Maria Harrison
Arbuscular mycorrhizal fungi extend long filament-like structures called hyphae far out into the soil. The hyphae, which are smaller than a human hair, cultivate their own microbiome.
A team of researchers from the Boyce Thompson Institute (BTI) has discovered a distinct group of bacteria that may help fungi and plants acquire soil nutrients. The findings could point the way to cost-effective and eco-friendly methods of enriching soil and improving crop yields, reducing farmers' reliance on conventional fertilizers.

Researchers know that arbuscular mycorrhizal (AM) fungi establish symbiotic relationships with the roots of 70% of all land plants. In this relationship, plants trade fatty acids for the fungi's nitrogen and phosphorus. However, AM fungi lack the enzymes needed to free nitrogen and phosphorus from complex organic molecules.

A trio of BTI scientists led by Maria Harrison, the William H. Crocker Professor at BTI, wondered whether other soil microbes might help the fungi access those nutrients. In a first step towards examining that possibility, the team investigated whether AM fungi associate with a specific community of bacteria. The research was described in a paper published in The ISME Journal on March 1.

Comment: Research is also revealing that conventional agriculture destroys these symbiotic relationships:


Blue Planet

Dinosaur-killing asteroid strike gave rise to Amazon rainforest

asteroid
© SPL
The asteroid impact 66 million years ago led not just to the extinction of dinosaurs, but other forms of life
The asteroid impact that killed off the dinosaurs gave birth to our planet's tropical rainforests, a study suggests.

Researchers used fossil pollen and leaves from Colombia to investigate how the impact changed South American tropical forests.

After the 12km-wide space rock struck Earth 66 million years ago, the type of vegetation that made up these forests changed drastically.

The team has outlined its findings in the prestigious journal Science.

Comment: As Pierre Lescaudron concludes in his article The Seven Destructive Earth Passes of Comet Venus, it would appear that extinction level events are followed by an explosion of life on our planet:
Despite their apparent remoteness, cometary events are very real and might actually be one of the main punctuators of life and death on Earth. Most mass extinctions were triggered by cometary events and, interestingly, they were followed by the appearance of more complex forms of life.

We can witness this phenomenon, for example, at the Eoceone-Oligocene (E-O) boundary where numerous Eocene species went extinct and were "replaced" by the more complex Oligocene fauna:
Even more open landscapes allowed animals to grow to larger sizes than they had earlier in the Paleocene epoch 30 million years earlier. Marine faunas became fairly modern, as did terrestrial vertebrate fauna on the northern continents. This was probably more as a result of older forms dying out than as a result of more modern forms evolving.
Source
There is a similar pattern at the Cretaceous-Paleogene (K-Pt) boundary (attributed to the Chicxulub impact) where numerous Cretaceous species went extinct and were 'replaced' by the more complex Paleogene fauna:
The Paleogene is most notable for being the time during which mammals diversified from relatively small, simple forms into a large group of diverse animals in the wake of the Cretaceous-Paleogene extinction event that ended the preceding Cretaceous Period.
Source
If major cometary impacts trigger jumps in the complexity of life on our planet, the question is: how? One possible mechanism is via cometary-borne viruses. The presence of organic material in comets is now hypothesized by mainstream science. And we know that viruses can transfer DNA to their hosts.

So, are major cometary events the window of opportunity that 'intelligent design' uses to remove obsolete life forms (mass extinction) and to introduce more elaborate life-forms (life explosion) via the new DNA codes carried by the accompanying viruses?

That will be the topic of a future article.
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