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The white blood cell population inside the human heart isn't as uniform as previously thought.
Researchers have shown that two genetically and functionally distinct types of macrophage -white blood cells that engulf foreign matter - exist in the human heart.
The discovery, by a team led Geetika Bajpai from Washington University in Missouri, US, is revealed in
a paper published in the journal
Nature Medicine. It has important implications for the development of targeted immune treatments for patients with a particularly insidious type of heart disease.
Macrophages are the mammoth cells that detect, hoover up and destroy microbes and other invaders. The cells are not uniform, however, and are classified into subtypes. Two - dubbed CCR2-plus and CCR2-minus - were
identified in mouse hearts in the 1960s, and have been exhaustively researched ever since.
Different macrophage subtypes have previously been found in human organs, including the
skin,
lungs and
eyes, but this is the first study to prove that CCR2-plus and CCR2-minus are found in the human heart.
They were located in samples taken from the left heart chamber of patients with two kinds of cardiomyopathy (CM). This is a condition in which the heart muscle becomes stretched thin and cannot function, leading to heart failure. The only plausible treatments are the insertion of a device into the heart to help it function, or getting a new ticker altogether.
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