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From Richard Lenski’s terrific LTEE
This is the fourth in a series of posts responding to the extended critique of
Darwin Devolves by Richard Lenski at his blog,
Telliamed Revisited. Professor Lenski is perhaps the most qualified scientist in the world to analyze the arguments of my book. He is the Hannah Distinguished Professor of Microbial Ecology at Michigan State University, a MacArthur ("Genius Award") Fellow, and a member of the National Academy of Sciences with hundreds of publications. He also has a strong interest in the history and philosophy of science. His own laboratory evolution work is a central focus of the book. I am very grateful to Professor Lenski for taking time to assess
Darwin Devolves. His comments will allow interested readers to quickly gauge the relative strength of arguments against the book's thesis.
"Solid and Interesting"
In his fourth post, "
Evolution goes viral! (And how real science works)," Professor Lenski revisits a series of experiments on the bacteriophage lambda begun by his lab around 2012. Briefly, bacteriophages are viruses that invade and eat bacterial cells. Lambda specializes in eating
E. coli cells. In order to invade the cell, lambda has to bind to a specific bacterial membrane protein, dubbed LamB, to gain a foothold. The Michigan lab grew a strain of
E. coli that had lost much (but not all) of its ability to make LamB, together in a culture with bacteriophage lambda. The lambda had a much more difficult time invading those bacterial cells than normal ones, since its docking site was much rarer.
Over time, however, lambda acquired mutations in the protein (called "J") that is responsible for binding LamB of
E. coli. The mutations allowed it to bind to a second
E. coli membrane protein, OmpF. Mutant phages could then invade cells that were unavailable to unmutated phages, so they prospered. When Lenski's then-student
Justin Meyer investigated, he saw that
at least four specific amino acid changes had occurred, and all of them were necessary for the new ability to bind OmpF.
Lenski's current post emphasizes that requirement for multiple mutations, so the new interaction seems to him to be irreducibly complex and beyond the "edge of evolution." What's more, nothing was broken, so that contradicts the main argument of
Darwin Devolves, he thinks.
Comment: See also: