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Genetic-based Human Diseases Are An Ancient Evolutionary Legacy, Research Suggests

Tomislav Domazet-Lošo and Diethard Tautz from the Max Planck Institute for Evolutionary Biology in Plön, Germany, have systematically analysed the time of emergence for a large number of genes - genes which can also initiate diseases. Their studies show for the first time that the majority of these genes were already in existence at the origin of the first cells.
Artistic illustration of a phylostratigraphy
© Irena Andreic, Ruđer Bošković Institute, Zagreb
Artistic illustration of a phylostratigraphy.

The search for further genes, particularly those which are involved in diseases caused by several genetic causes, is thus facilitated. Furthermore, the research results confirm that the basic interconnections are to be found in the function of genes - causing the onset of diseases - can also be found in model organisms (Molecular Biology and Evolution).

The Human Genome Project that deciphered the human genetic code, uncovered thousands of genes that, if mutated, are involved in human genetic diseases. The genomes of many other organisms were deciphered in parallel. This now allows the evolution of these disease associated genes to be systematically studied.

Telescope

Ghostly Glow Reveals Galaxy Clusters In Collision

A team of scientists, including astronomers from the Naval Research Laboratory (NRL), have detected long wavelength radio emission from a colliding, massive galaxy cluster which, surprisingly, is not detected at the shorter wavelengths typically seen in these objects.
Superimposed false-color images of the galaxy cluster A521
© Radio (NCRA/GMRT/INAF/G.Brunetti et al.); X-ray (NASA/CXC/INAF/S.Giacintucci et al.)
Superimposed false-color images of the galaxy cluster A521. The blue color represents hot gas typical of many galaxy clusters detected by the Chandra X-ray Observatory. The shape of the X-ray emission indicates that the cluster has undergone a recent collision or "merger event" that could generate turbulent waves. The red represents radio emission at 125 cm wavelength. The bright radio source on the lower left periphery of the X-ray gas is a separate source. The region of radio emission generated by turbulent waves is located at the center of the cluster, where the colors overlap.

The discovery implies that existing radio telescopes have missed a large population of these colliding objects. It also provides an important confirmation of the theoretical prediction that colliding galaxy clusters accelerate electrons and other particles to very high energies through the process of turbulent waves. The team revealed their findings in the October 16, 2008 edition of Nature.

This new population of objects is most easily detected at long wavelengths. Professor Greg Taylor of the University of New Mexico and scientific director of the Long Wavelength Array (LWA) points out, "This result is just the tip of the iceberg. When an emerging suite of much more powerful low frequency telescopes, including the LWA in New Mexico, turn their views to the cosmos, the sky will 'light up' with hundreds or even thousands of colliding galaxy clusters." NRL has played a key role in promoting the development of this generation of new instruments and is currently involved with the development of the LWA. NRL radio astronomer and LWA Project Scientist Namir Kassim says "Our discovery of a previously hidden class of low frequency cluster-radio sources is particularly important since the study of galaxy clusters was a primary motivation for development of the LWA."

Satellite

NASA's Ibex Launches for Examination of Sun's Weakening Shield

NASA launched its Interstellar Boundary Explorer, or Ibex, into orbit today for an examination of the solar winds that shield the Earth from harmful cosmic rays.

Ibex will give scientists a better understanding of how the solar wind -- made of magnetically charged particles -- interacts with the larger galaxy. The winds have fallen to the weakest level in half a century.

Much as the Earth's magnetic field repels cosmic rays, the solar wind protects the entire solar system. Ions, expelled by the sun in every direction at 1 million miles (1.6 million kilometers) per hour, create a ''bubble.'' This shield screens 90 percent of the intense, stellar radiation pulsing throughout the galaxy, said the National Aeronautics and Space Administration.

Telescope

NASA Hits Snag in Reviving Hubble Space Telescope

NASA's attempt to revive the ailing Hubble Space Telescope has hit a snag, leaving the iconic observatory's return to science observations in limbo until two new glitches can be solved, agency officials said Friday.

The new issues cropped up on Thursday while engineers were attempting to switch Hubble to a backup data relay channel and restore the telescope's ability to beam images and data back to Earth following a hardware failure last month.

"We think the soonest that we would be back doing full science would be sometime late next week," said Art Whipple, chief of NASA's Hubble systems management office at Goddard Space Flight Center in Greenbelt, Md., in a Friday teleconference.

Telescope

Canadian researchers uncover tool for hunting dark matter

Researchers at the Sudbury Neutrino Observatory say they have developed a new technique in the search for dark matter, the invisible substance or group of substances that make up a large percentage of the universe.

The Picasso group, made up of researchers from Canada, the United States and Czech Republic, said the new method will clear out background noise from other particles to give detectors a better shot at finding dark matter signals.

Dark matter is an important part of our picture of the universe - its gravitational influence helps explain why stars at the edges of galaxies appear to move at the same speed as those near the centre, for example.

Robot

Scientists give new life to paralyzed limbs by rewiring brain

Researchers at the University of Washington are working to reroute brain signals in an effort to give paralyzed people the ability to move their limbs again.

By creating an artificial connection between nerve cells in the brain and muscles, scientists say they are restoring voluntary movement to the once-paralyzed limbs, according to a report from the University of Washington in Seattle. The rerouting effectively bypasses damaged nerves in subjects with spinal cord injuries, which generally damage nerves but leave muscles and brain tissue unharmed.

Research that involves making new connections in living brains and even connecting robots to living brains has been gaining a lot of attention in the past year.

Telescope

Problems crop up on Hubble Space Telescope

Cape Canaveral, FL - Science observations aboard the Hubble Space Telescope were on hold on Friday following a pair of problems that cropped up as the observatory recovered from a computer failure, NASA said.
Hubble Space Telescope's hardware modules
© REUTERS/NASA
Two engineers in the Space Telescope Operations Control Center sit at consoles during the switch of the Hubble Space Telescope's hardware modules, October 15, 2008.

Engineers successfully switched Hubble to a backup computer on Thursday and were watching as the telescope's instruments were automatically reactivating.

However on Friday NASA posted a notice on its website saying "the activation of the telescope's science instruments and resumption of observations has been suspended following two anomalies seen in systems on the telescope Thursday."

A news conference was planned for later on Friday.

Magnify

Scientists Propose Creation Of New Type Of Seed Bank

While an international seed bank in a Norwegian island has been gathering news about its agricultural collection, a group of U.S. scientists has just published an article outlining a different kind of seed bank, one that proposes the gathering of wild species - - at intervals in the future - - effectively capturing evolution in action.
Scientist Susan Mazer
© UCSB
Scientist Susan Mazer in a UCSB greenhouse.

In the October issue of Bioscience, Steven J. Franks of Fordham University, Susan J. Mazer of the University of California, Santa Barbara, and a group of colleagues, have proposed a method of collecting and storing seeds of natural plant populations. They argue for the collection of many species in a way that evolutionary responses to future changes in climate can be detected. They call it the "Resurrection Initiative."

"In contrast to existing seed banks, which exist primarily for conservation, this collection would be for research that would allow a greater understanding of evolution," said Franks.

"This seed collection would form an important resource that can be used for many types of research, just as GenBank - - the collection of genetic sequences and information - - forms a key resource for research in genetics and genomics," said Franks.

"Typically, seed banks are focused on the preservation of agricultural species or other plant species of strong economic interest, say, forest species, forest trees," said Mazer. This is to make sure that scientists can maintain a genetically diverse seed pool in the event of some kind of ecological calamity that requires the replenishing of seeds from a certain part of the world or from certain species. "But that implies a relatively static view of a seed bank, a snapshot forever of what a species provides."

Sherlock

Finding Hidden Tomb Of Genghis Khan Using Non-Invasive Technologies

According to legend, Genghis Khan lies buried somewhere beneath the dusty steppe of Northeastern Mongolia, entombed in a spot so secretive that anyone who made the mistake of encountering his funeral procession was executed on the spot.

Once he was below ground, his men brought in horses to trample evidence of his grave, and just to be absolutely sure he would never be found, they diverted a river to flow over their leader's final resting place.
Genghis Khan
© UC San Diego
A 14th-century portrait of Genghis Khan. The painting is now located in the National Palace Museum in Taipei, Taiwan.

What Khan and his followers couldn't have envisioned was that nearly 800 years after his death, scientists at UC San Diego's Center for Interdisciplinary Science in Art, Architecture and Archaeology (CISA3) would be able to locate his tomb using advanced visualization technologies whose origins can be traced back to the time of the Mongolian emperor himself.

Telescope

Colossal Black Holes Common In Early Universe, Spectacular Galactic Collision Suggests

Astronomers think that many - perhaps all - galaxies in the universe contain massive black holes at their centers. New observations with the Submillimeter Array now suggest that such colossal black holes were common even 12 billion years ago, when the universe was only 1.7 billion years old and galaxies were just beginning to form.
4C60.07 system of colliding galaxies
© David A. Hardy/UK ATC
Artist’s conception of the 4C60.07 system of colliding galaxies. The galaxy on the left has turned most of its gas into stars, and the black hole in its center is ejecting charged particles in the two immense jets shown. The galaxy on the right also has a black hole causing the galaxy’s central region to shine, but much of its light is hidden by surrounding gas and dust. Vast numbers of stars are forming out of the gas and dust, and some of the material is being pulled away from the galaxy.

The new conclusion comes from the discovery of two distant galaxies, both with black holes at their heart, which are involved in a spectacular collision.

4C60.07, the first of the galaxies to be discovered, came to astronomers' attention because of its bright radio emission. This radio signal is one telltale sign of a quasar - a rapidly spinning black hole that is feeding on its home galaxy.

When 4C60.07 was first studied, astronomers thought that hydrogen gas surrounding the black hole was undergoing a burst of star formation, forming stars at a remarkable rate - the equivalent of 5,000 suns every year. This vigorous activity was revealed by the infrared glow from smoky debris left over when the largest stars rapidly died.