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The impossible protein: Research confirm's Doug Axe on the rarity of functional proteins

Saraha desert
© Luca Galuzzi, via Wikimedia Commons
In a previous article I described the evidence that cooption faces insurmountable mathematical challenges in explaining the origins of such complex molecular machines as the bacterial flagellum. Some of my argument relies on the evidence that novel proteins are exceedingly difficult to evolve. In discussions with critics, several important questions were raised which led me to further research studies addressing the effect of mutations on protein stability. I found that the consistent results of key studies decisively confirm the conclusion of Doug Axe that most natural proteins are too rare to evolve through an undirected search.

Accumulating Mutations

As I noted earlier, evolutionists argue that each protein comprising a flagellum resulted from the duplication of an existing gene which then continuously mutated until it stumbled upon a new flagellar function. However, research over the past several years has shown this claim to be implausible. Understanding why will require a few steps of analysis. To begin, experiments on such model proteins as β-lactamase and HisA demonstrate that their activity declines increasingly rapidly as mutations that change amino acids accumulate, and the mutations' deleterious effects also increase.

As a specific example, the Tokuriki and Tawfik study demonstrated the following effects of accumulating mutations:
  • After only a few random mutations (1-2) under weak selection, around a third of subsequent changes to a protein completely disable it.
  • After several more mutations accumulate (5-6), the protein is inactivated by slightly under two-thirds of subsequent changes.
  • After random alteration of less than 10 percent of the protein's initial sequence, it becomes permanently nonfunctional (fitness approaches zero).
The corresponding rarity (ratio of functional to nonfunctional amino acid sequences) can be calculated working backwards. The number of sequences that differ from an optimal one by a given number of amino acids increases almost exponentially with the number, so a random search would find a barely functional sequence long before an optimized one. Therefore, estimating the upper limit for the probability of a successful trial must focus on this neighborhood of sequence space (map of all possible sequences).

Fireball

Asteroid the size of Big Ben will skim past Earth today

asteroid
A massive asteroid believed to measure 280ftin diameter is set to fly past Earth this afternoon at a dizzying speed of 30,422 miles per hour.

The asteroid, dubbed 2013 MD8, is expected to skim past Earth at just over 3 million miles away, or about 13 times the distance between Earth and the moon, at 12:55pm (ET) on Tuesday.

The huge space rock is expected to make a 'close approach' to Earth, but its trajectory should see it soar safely by.

The asteroid, dubbed 2013 MD8, is expected to skim past Earth at just over 3 million miles away, or about 13 times the distance between Earth and the moon, at 12:55pm (ET) on Tuesday

NASA considers an asteroid to be 'hazardous' if they come within 4,600,000 miles of our planet.

Comment: NASA has documented a sharp uptick in NEOs which potentially pose a threat to civilization, but more concerning are these that we have yet to detect. As noted in the article Earth enters densest stream of deadly Taurid meteor cluster this June:
But moving down the size scale, the census is far spottier. Only about 30 percent of medium-size objects - 140 meters (460 feet) in diameter or larger - have been spotted. And she said only about 1 percent of objects have been found that are the size of the Tunguska impactor, which was about 40 meters (130 feet) in diameter. She said she welcomed the idea of a special effort to look for objects during the Taurid swarm in June.
And if an asteroid the size of that in Tunguska struck over a major city it would cause mass mortality.

See also: And to hear what the historical records have to say on the matter, check out SOTT radio's: Behind the Headlines: Who was Jesus? Examining the evidence that Christ may in fact have been Caesar!


Info

New 'shape' for coronal mass ejections revealed during observations

Coronal mass ejection
© LV4260/Getty Images
An artist's impression of a coronal mass ejection.
Astronomers using one of the most sensitive arrays of radio telescopes in the world have caught a huge storm erupting on the sun and observed material flung from it at more than 3000 kilometres a second, a massive shockwave and phenomena known as herringbones.

In the journal Nature Astronomy, Diana Morosan from the University of Helsinki in Finland and her colleagues report detailed observations of the huge storm, a magnetic eruption known as a coronal mass ejection (CME).

Unlike the herringbones a biologist might find while dissecting, well, a herring, the team found a data-based version while dissecting the radio waves emitted during the violent event.

The shape of the fish skeleton emerged when they plotted the frequencies of radio waves as the CME evolved. The spine is a band of emission at a constant frequency, while the vertical offshoot "bones" on either side were sudden short bursts of radiation at a much wider range of frequencies.

Herringbones have been found in the sun's radio-wave entrails before, but this is the first time that such a sensitive array of radio telescopes has recorded them. The detailed data enabled Morosan and colleagues for the first time to pin down the origin of the radiation bursts.

To their surprise, the bones were being created in three different locations, on the sides of the CME.

"I was very excited when I first saw the results, I didn't know what to make of them," Morosan says.

Blue Planet

Russia's private "space yachts" to fly tourists to near-Earth orbit in 5 years

Selena Space Yacht
© NPO Aviation and Space Technologies
Selena Space Yacht
Private space tourism is taking off in Russia with plans to send tourists to near-Earth orbit in spacecraft capable of launching from ordinary airfields, chief designer of NPO Aviation and Space Technologies Aleksandr Begak said.

He told Sputnik news agency the first flights may start in five years and will cost about $200,000 to $300,000 per person.

According to Begak, a number of private companies are currently working on the unmanned spacecraft dubbed Selena Space Yacht. The works are conducted with the support of the National Technology Initiative's (NTI) AeroNet and SpaceNet working groups.

Comment: See also:


Brain

Entirely new form of communication observed in the brain: non-linear information transfer via self-propagating electric fields

Brain
Case Western Reserve researchers observe waves 'leap' across cut in brain tissue; 'ephaptic coupling' said to be producing self-propagating waves, unknown until now

Biomedical engineering researchers at Case Western Reserve University say they have identified a previously unidentified form of neural communication, a discovery that could help scientists better understand neural activity surrounding specific brain processes and brain disorders.

"We don't know yet the 'So what?' part of this discovery entirely," said lead researcher Dominique Durand, the Elmer Lincoln Lindseth Professor in Biomedical Engineering and director of the Neural Engineering Center at the Case School of Engineering. "But we do know that this seems to be an entirely new form of communication in the brain, so we are very excited about this."

Until now, there were three known ways that neurons "talk" to each other in the brain: via synaptic transmission, axonal transmission and what are known as "gap junctions" between the neurons.

Comment: Not long to go now till their jaws drop upon discovering that we're wave-reading consciousness units connected to The Information Field...


Telescope

In the blink of an eye: Astronomers seek backup to capture strange stellar blackout with help of cell phone cameras

Sirius star hubble image
© ESA / Hubble and Digitized Sky Survey 2
A Hubble spacecraft image of Sirius
A rare and fleeting stellar blackout is being hailed by astronomers as the perfect opportunity to ask budding stargazers for help in accurately plotting the brightest object we can see from Earth.

A 2.8-mile-wide (4.6km) asteroid called Jurgenstock will pass in front of the double star system Sirius on Monday night, briefly blocking its powerful shine and casting an eclipse-like shadow across Earth for approximately 20 minutes.

The so-called occultation will be fleetingly visible over parts of southern Argentina, southern Chile, Central America and the Caribbean at around 10:30pm MST on Monday evening. And the circumstances of the celestial event are so unusual that astronomers are issuing a strange plea to any potential witnesses.

Rocket

No limits? Here's what we know about 'Russian Tomahawks', Moscow's new nuclear cruise missile

Russia Missile

Russian missile development facilities, undisclosed location
Russia's new nuclear cruise missile has entered the final stage of development following reports of successful tests. Officials say Burevestnik ('Storm Petrel') will have "unlimited" range and can outmaneuver any known defenses.

The missile's nuclear power unit was successfully tested back in January, Russian media reported on Friday, citing sources. This "crucial" stage of testing "confirmed" that the reactor allows the missile to travel to an "unlimited range."

The military didn't officially confirm the story, and it is not clear where and when the test reportedly took place. The videos released by the missile's development team earlier showed how the engineers, dressed in all white and wearing safety masks, were carefully examining the prototype at an undisclosed location. The weapon itself was partially covered in the footage.


The weapon's ambitious concept was unveiled by President Vladimir Putin during his State of the Nation address last March. The 9M730 Burevestnik, known as SSC-X-9 Skyfall under its NATO reporting name, is designed as a nuclear-powered and nuclear-armed intercontinental cruise missile capable of traveling "unlimited distances." It is even able to circle around the globe for days, if required.

Info

New fabrics grown in fermenting tanks could stop tiny plastic fibres polluting the world's oceans

Fabric
New fabrics being grown in laboratories may provide a viable alternative to the materials currently shedding vast quantities of plastic into the world's oceans.

Synthetic textiles like polyester are durable replacements for natural fabrics like wool and cotton, but they also contribute to the trillions of microplastics filling the world's oceans.

Concern has been growing about this form of pollution, which is known to be consumed by underwater wildlife with potentially harmful health effects.

These tiny shards of plastic come from many sources, but by far the most abundant variety is thought to be microfibres.

Comment: See also:


Info

New research suggest common gut virus linked to coeliac disease

Coeliac Disease
© SOLSTOCK/GETTY IMAGES
Developing coeliac disease in later life could be linked to a viral infection during childhood.
A group of common intestinal viruses may be a trigger for coeliac disease in children who have a genetic predisposition for the disease, according to research published in The BMJ journal.

The research details the results of a 15-year study, led by Christian Kahrs of the Østfold Hospital Trust, Grålum, in Norway, that included 220 children with genes that made them more susceptible to the condition. Of these, 25 went on to develop the disease.

The scientists found that these participants were more likely than non-coeliacs to test positive for a group of gut bugs known as enteroviruses.

Enterovirus infections are common and often produce mild symptoms such as runny noses, vomiting and illnesses including hand, foot and mouth disease.

"We found a significant association between exposure to enterovirus and subsequent risk of coeliac disease," the researchers write.

"This study suggests that infections with enterovirus in early life could be one among several key risk factors for development of a disease with lifelong consequences."

Bizarro Earth

Mountains buried 400 miles underground 'could be bigger than Everest'

Underground mountains
© Princeton University
A study by Princeton scientists into the boundary between the upper and lower mantle of the Earth have surprisingly found topography potentially 'rougher' than any mountain on Earth. They are located at a boundary 410 miles (600 kilometers) straight down into the Earth from the planet's surface.
An underground 'mountain' has been discovered that lies 410 miles beneath the Earth's surface that's taller than Everest.

A study by Princeton scientists into the boundary between the upper and lower mantle of the Earth have surprisingly found ridges and clefts that are potentially rougher than anything on Earth.

They are located at a boundary 410 miles (600 kilometers) straight down into the earth from the planet's surface.

Dr Wenbo Wu, one of the geophysicists on the paper said: 'In other words, stronger topography than the Rocky Mountains or the Appalachians is present at the 660-km boundary'.

Using wave data from a 8.2 magnitude earthquake in Bolivia, mountains and other topography were discovered on the base of the boundary.

The earthquake was the second-largest deep earthquake ever recorded and took place in 1994.

The most powerful waves on the planet come from giant earthquakes, that can generate shock waves which travel through the Earth's core to the other side of the planet in all directions and back again.

The data from the shock waves allow data scientists to study deep into the Earth by modelling wave data on the kind of topography that could have caused it to scatter in such a way.