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Microscope 2

Chinese study finds coronavirus uses same strategy as HIV to dodge immune response

coronavirus
© Shutterstock
The novel coronavirus uses the same strategy to evade attack from the human immune system as HIV, according to a new study by Chinese scientists.

Both viruses remove marker molecules on the surface of an infected cell that are used by the immune system to identify invaders, the researchers said in a non-peer reviewed paper posted on preprint website bioRxiv.org on Sunday. They warned that this commonality could mean Sars-CoV-2, the clinical name for the virus, could be around for some time, like HIV.

Virologist Zhang Hui and a team from Sun Yat-sen University in Guangzhou also said their discovery added weight to clinical observations that the coronavirus was showing "some characteristics of viruses causing chronic infection".

Butterfly

Scientist admits biologists are obsessed with discrediting Intelligent Design

biology engineers laboratory
© ThisisEngineering RAEng/Unsplash
What do scientists spend more time thinking about — sex, or the theory of intelligent design? Scientific research famously gives a range of answers to the question of how many times per day men think about sex (from 19 times to 7,200 times). If one European researcher is correct, scientists in the United States (who are mostly male) spend one-fifth of their waking time thinking about how to "combat intelligent design." Despite incessant declarations that "there is no controversy" about evolution, ID is evidently on the mind of many biologists, to the point of obsession!

Evolution News recently commented on an article in an Italian philosophy journal that took intelligent design (ID) arguments with refreshing seriousness. Now another European journal has published its own noteworthy commentary. The author is Giuseppe Longo, who studies mathematical computer science and epistemology as research director (emeritus) at Le Centre national de la recherche scientifique (National Center for Scientific Research) in Paris. His article, "Scientific thought and absolutes for an image of the sciences, between computing and biology," appears in the humanities journal Angelaki.

Fireball 3

Bad day: Dinosaur-dooming asteroid struck Earth at the deadliest possible angle

asteroid impact mexico dinosaurs
© Chase Stone
Original artwork depicting the moment the asteroid struck in present-day Mexico.
New simulations from Imperial College London have revealed the asteroid that doomed the dinosaurs struck Earth at the 'deadliest possible' angle.

The simulations show that the asteroid hit Earth at an angle of about 60 degrees, which maximised the amount of climate-changing gases thrust into the upper atmosphere.

Such a strike likely unleashed billions of tonnes of sulphur, blocking the sun and triggering the nuclear winter that killed the dinosaurs and 75 per cent of life on Earth 66 million years ago.

Drawn from a combination of 3-D numerical impact simulations and geophysical data from the site of the impact, the new models are the first ever fully 3-D simulations to reproduce the whole event — from the initial impact to the moment the final crater, now known as Chicxulub, was formed.

The simulations were performed on the Science and Technology Facilities Council (STFC) DiRAC High Performance Computing Facility.

Blue Planet

Inherited Neanderthal gene in women causes increased birth rate

Neanderthal
© Universal Images Group North America LLC/Alamy
A Neanderthal skull.
One third of women living in Europe today have inherited the receptor for progesterone from the Neandertals according to a new study by researchers from the Max Planck Institute.

Progesterone is a gene variant, associated with increased fertility, fewer bleedings during early pregnancy and fewer miscarriages.

"The progesterone receptor is an example of how favourable genetic variants that were introduced into modern humans by mixing with Neandertals can have effects in people living today," says Hugo Zeberg, researcher at the Department of Neuroscience at Karolinska Institutet and the Max Planck Institute for Evolutionary Anthropology, who performed the study with colleagues Janet Kelso and Svante Pääbo.

Comment: See also:


Chalkboard

Graduate student solves decades-old Conway Knot Problem

Lisa Piccirillo
© Ian MacLellan/Quanta Magazine
Lisa Piccirillo’s solution to the Conway knot problem helped her land a tenure-track position at the Massachusetts Institute of Technology.
It took Lisa Piccirillo less than a week to answer a long-standing question about a strange knot discovered over half a century ago by the legendary John Conway.

In the summer of 2018, at a conference on low-dimensional topology and geometry, Lisa Piccirillo heard about a nice little math problem. It seemed like a good testing ground for some techniques she had been developing as a graduate student at the University of Texas, Austin.

"I didn't allow myself to work on it during the day," she said, "because I didn't consider it to be real math. I thought it was, like, my homework."

The question asked whether the Conway knot — a snarl discovered more than half a century ago by the legendary mathematician John Horton Conway — is a slice of a higher-dimensional knot. "Sliceness" is one of the first natural questions knot theorists ask about knots in higher-dimensional spaces, and mathematicians had been able to answer it for all of the thousands of knots with 12 or fewer crossings — except one. The Conway knot, which has 11 crossings, had thumbed its nose at mathematicians for decades.

Telescope

More than 120 of Earth's largest telescopes are now closed due to COVID-19

Earth's largest optical telescope, the Gran Telescopio Canarias, is closed due to COVID-19
© Instituto de Astrofísica de Canarias
Earth's largest optical telescope, the Gran Telescopio Canarias, is closed due to COVID-19. Many others have also closed.
The alarm sounded at around 3 a.m. on April 3. An electrical malfunction had stalled the behemoth South Pole Telescope as it mapped radiation left over from the Big Bang. Astronomers Allen Foster and Geoffrey Chen crawled out of bed and got dressed to shield themselves from the -70 degree Fahrenheit temperatures outside. They then trekked a few thousand feet across the ice to restart the telescope.

The sun set weeks ago in Antarctica. Daylight won't return for six months. And, yet, life at the bottom of the planet hasn't changed much — even as the rest of the world has been turned upside-down. The last flight from the region left on Feb. 15, so there's no need for social distancing. The 42 "winterovers" still work together. They still eat together. They still share the gym. They even play roller hockey most nights.

And that's why the South Pole Telescope is one of the last large observatories still monitoring the night sky.

An Astronomy magazine tally has found that more than 100 of Earth's biggest research telescopes have closed in recent weeks due to the COVID-19 pandemic. What started as a trickle of closures in February and early March has become an almost complete shutdown of observational astronomy. And the closures are unlikely to end soon.

Observatory directors say they could be offline for three to six months — or longer. In many cases, resuming operations will mean inventing new ways of working during a pandemic. And that might not be possible for some instruments that require teams of technicians to maintain and operate. As a result, new astronomical discoveries are expected to come to a crawl.

"If everybody in the world stops observing, then we have a gap in our data that you can't recover," says astronomer Steven Janowiecki of the McDonald Observatory in Texas. "This will be a period that we in the astronomy community have no data on what happened."

Yet these short-term losses aren't astronomers' main concern.

Nebula

The 'Cow' mystery strikes back: Two more rare, explosive events captured

FBOTs
© Bill Saxton, NRAO/AUI/NSF
Artist’s illustration detailing the structure of FBOTs.
The 'Cow' is not alone; with the help of W. M. Keck Observatory on Maunakea in Hawaii, astronomers have discovered two more like it — the 'Koala' and a similar mysterious bright object called CSS161010. This trio of fast blue optical transients (FBOTs) appear to be relatives, all belonging to a highly-luminous family that has a track record for surprising astronomers with their fast, powerful bursts of energy.

The 'Koala,' which is a nickname derived from the tail end of its official name ZTF18abvkwla, suddenly appeared as a bright new source in the optical sky before disappearing within just a few nights. A team of astronomers at Caltech realized this behavior was similar to the 'Cow' and requested radio observations to see if the two were connected.

"When I reduced the data, I thought I made a mistake," said Anna Ho, graduate student of astronomy at Caltech and lead author of the study. "The 'Koala' resembled the 'Cow' but the radio emission was ten times brighter — as bright as a gamma-ray burst!"

Comment: For more dazzling discoveries of late, see:


Nebula

'Hot and messy' entanglement of 15 trillion atoms

atoms
© ICFO
Artistic illustration of a cloud of atoms with pairs of particles entangled between each other, represented by the yellow-blue lines.
Quantum entanglement is a process by which microscopic objects like electrons or atoms lose their individuality to become better coordinated with each other. Entanglement is at the heart of quantum technologies that promise large advances in computing, communications and sensing, for example, detecting gravitational waves.

Entangled states are famously fragile: In most cases, even a tiny disturbance will undo the entanglement. For this reason, current quantum technologies take great pains to isolate the microscopic systems they work with, and typically operate at temperatures close to absolute zero. The ICFO team, in contrast, heated a collection of atoms to 450 Kelvin in a recent experiment, millions of times hotter than most atoms used for quantum technology. Moreover, the individual atoms were anything but isolated; they collided with each other every few microseconds, and each collision set their electrons spinning in random directions.

Comment: See also:


Info

Chicxulub simulations reveal trajectory of impact

Chicxulub Crater
© Gareth Collins/Imperial College London
Asymmetries of the Chicxulub crater.
The asteroid that most believe wiped out the dinosaurs struck at the deadliest possible angle, according to new analysis combining 3D numerical impact simulations and geophysical data from the site.

The 66-million-year-old Chicxulub crater in Mexico was formed by a steeply inclined impact of between 45 and 60 degrees to the horizontal, the researchers suggest, which maximised the amount of climate-changing gases thrust into the upper atmosphere.

Such a strike likely unleashed billions of tonnes of sulphur, blocking the Sun and triggering the nuclear winter that killed 75% of life on Earth.

The researchers - from Imperial College London (ICL), the University of Freiburg, Germany, and the University of Texas, US - say their models are the first fully 3D simulations to reproduce the whole dramatic event, from the initial impact to the crater formation.

Reproducing the final stage, in which the transient crater collapsed to form the final structure, allowed them to make the first comparison between 3D simulations and the present-day structure of the crater.

"Our simulations provide compelling evidence that the asteroid struck at a steep angle, perhaps 60 degrees above the horizon, and approached its target from the northeast," says ICL's Gareth Collins, lead author of a paper in the journal Nature Communications.

Bullseye

'Darwin Devolves' thesis vindicated again: Sherpas climb Everest easier because of 'broken genes'

mt everest climbers
© Lloyd Smith, via Wikimedia Commons
Climbers on Mount Everest
How can Tibetans survive high altitudes that leave lowlanders gasping? The answer is found in broken genes. A new paper on the Tibetan genome vindicates what Michael Behe said in Darwin Devolves: evolution breaks things, but sometimes, like in the case of polar bears, the result can allow organisms to thrive in specific environments. Yes, this follows on the heels of last week's Behe vindication; see here.

A team of 16 scientists, writing in PNAS, sought to understand the genetic basis for Tibetan high-altitude adaptation in more detail. Tibetans and Nepalese, many of whom serve as guides for lowlanders wanting to conquer Mount Everest, routinely carry heavy burdens at altitudes above 14,000 feet, the average elevation on the Tibetan plateau. In its entry on Sherpa people, Wikipedia notes,
Many Sherpa are highly regarded as elite mountaineers and experts in their local area. They were immeasurably valuable to early explorers of the Himalayan region, serving as guides at the extreme altitudes of the peaks and passes in the region, particularly for expeditions to climb Mount Everest. Today, the term is often used by foreigners to refer to almost any guide or climbing supporter hired for mountaineering expeditions in the Himalayas, regardless of their ethnicity. Because of this usage, the term has become a slang byword for a guide or mentor in other situations. Sherpas are renowned in the international climbing and mountaineering community for their hardiness, expertise, and experience at very high altitudes. [Emphasis added.]

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