
Human neural stem cells (green) guided by electrical stimulation migrated to and colonized the subventricular zone of rats’ brains. This image was taken three weeks after stimulation.
When scientists applied electric current to human neural stem cells injected into rats' brains, the cells moved toward the animals' subventricular zone and lateral ventricle, instead of toward their olfactory bulb, the default destination. The result, published June 29 in Stem Cell Reports, suggests that electrical stimulation could one day be used to guide neural stem cells to damaged sites in the brain.
"This is the first study I've seen where stimulation is done with electrodes in the brain and has been convincing about changing the natural flow of cells so they move in the opposite direction," stem cell expert Alan Trounson of the Hudson Institute in Australia tells The Scientist. "The technique has strong possibilities for applications because the team has shown you can move cells, and you could potentially move them into seriously affected brain areas."
"I didn't expect the direction of the cells could be reversed," study coauthor Min Zhao of the University of California, Davis, tells The Scientist. The molecules that direct the flow of cells in the brain are very commanding, he says. Seeing that electrical stimulation can reverse the directions the cells travel shows the technique is "even more powerful than we thought" for guiding neural stem cells.














Comment: See also: Stem cells used for the first time to treat paralyzed man - and he regained upper body movement