Sherry Ershadi and John S. Barbieri, M.D., from Brigham and Women's Hospital in Boston, conducted a systematic review and meta-analysis to synthesize the available data regarding the safety and efficacy of at-home LED devices in the treatment of mild-to-moderate acne.
Based on data from six studies (216 participants; age range, 12 to 50 years), the researchers found that compared with control, the LED devices resulted in greater percent change in inflammatory lesions (45.3%; I2 = 43.2%; five studies), noninflammatory lesions (47.7%; I2 = 83.22%; four studies), and the Investigator Global Assessment (45.7%; I2 = 54.85%; four studies).
Red, blue, and combination wavelength devices were all effective. Benefit was typically seen after four to 12 weeks of use. There were no severe adverse reactions reported; however, a small number of patients did report mild dryness, erythema, or discomfort or pain during light therapy.
"At-home LED devices, particularly those that combine red and blue light, are efficacious for acne and can likely complement other over-the-counter and prescription treatments," the authors write.
Barbieri disclosed ties to Honeydew Care, Dexcel Pharma, and Sanofi Pasteur.
More information: Sherry Ershadi et al, At-Home LED Devices for the Treatment of Acne Vulgaris, JAMA Dermatology (2025). DOI: 10.1001/jamadermatol.2025.0019
Journal information: JAMA Dermatology
Comment: Acne has diverse causes and can significantly impact mental health, making this study on red light therapy promising, as it shows potential effectiveness.
If red light therapy hasn't significantly improved symptoms consider exploring the options below before turning to Accutane, antibiotics, or spironolactone. While these treatments can be effective in some cases, they may also come with serious side effects.
- Vitamin deficiencies
- Increased need for B5
- Hormonal imbalances
- Gut health
- Dietary changes (e.g., eliminating gluten and dairy)
- Sauna use
- Lymphatic drainage
- Psychological/spiritual factors
- Toxin/ mold exposure
- Herbalism & herbal skin creams
See also: Red light therapy benefits, research & mechanism of action and The Health & Wellness Show: Lightening up: The Benefits of Photobiomodulation