© Bucks Fire/TwitterTwo people were taken to hospital following the explosion.
A man was pulled from the wreckage by firefighters while an injured woman was also found at the scene.
The end-of-terrace property in Woodburn Green suffered major damage following the explosion, which happened at around 5.30pm.
An investigation into the blast is due to start on Monday, but it was initially thought to have been a gas explosion.
Police officers joined fire crews and members of the British Red Cross dealing with the incident.
Buckinghamshire Fire Service sent four crews to the scene, as well as two search and rescue vehicles and an incident command unit.
A fire service spokesman said: "Firefighters used two main jets and one hose reel and set up cordons.
"They rescued a man, injured. A woman was released, injured, before they arrived."
Five houses were evacuated following the explosion.
Fire crews were due to remain at the scene overnight.
Wooburn Green update: Crews will remain at the scene overnight. Fire investigation will start in the morning pic.twitter.com/IClDIZgYnE
— Bucks and MK Fire (@Bucksfire) November 22, 2015
Comment: Fire officer Adam Burch from High Wycombe Fire Station stated "An explosion of this kind is very rare, and especially to see a whole building collapse the way it has done".
There seems to have been an increase in the number of massive house explosions around the world in recent months, with investigators still attempting to determine the cause in many cases. Could a 'cosmic' source of ignition be responsible for some of these incidents?