The explosion caused a fire at the site, the factory's website said, as cited by TASS news agency.
Firefighters quickly arrived at the scene and the situation is reportedly under control.
No casualties have been reported.
It comes just three months after explosions at a chemical warehouse in Tianjin killed over 160 people and injured 700 others.
#BREAKING Blast reported at chemical factory in NE China's Liaoning; cause of blast is being investigated pic.twitter.com/xZRNMshrT1
— CCTVNEWS (@cctvnews) November 17, 2015
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