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Study finds iron-containing microglia in brain tissue of people with Alzheimer's disease

© Norbert von der Groeben
Michael Zeineh is the lead author of a study that describes the discovery of what appear to be cells containing iron in the postmortem brains of people with Alzheimer's disease.
Examining post-mortem tissue from the brains of people with Alzheimer's disease, Stanford University School of Medicine investigators identified what appear to be iron-containing microglia -- specialized scavenger cells that sometimes become inflammatory -- in a particular part of the hippocampus, a key brain structure whose integrity is critical to memory formation.

In post-mortem brain tissue from people not diagnosed with Alzheimer's, neither the iron deposits nor the scavenger cells engulfing them were present in that brain region.

The findings, recounted in a study now available online in Neurobiology of Aging, suggest that high-field magnetic resonance imaging, in particular an advanced version called 7T MRI that uses a powerful 7-Tesla magnet, could someday be used to diagnose and monitor Alzheimer's patients earlier than is currently possible.

The findings also add a new suspect to the Alzheimer's disease lineup. A long-held hypothesis holds that the most notorious feature of Alzheimer's disease, amyloid plaques, is the main cause of the disorder. These plaques are extracellular aggregations of a small protein called beta-amyloid that are prominent in diseased patients' brains, as well as in mouse models of the disease. The other most cited key player is tau, another Alzheimer's-associated protein that abnormally aggregates into threadlike tangles inside nerve cells. Surprisingly, in the brain region of interest there was no consistent overlap between the iron-laden microglia and the amyloid plaques or tau.

Comment:


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Brain changes caused by poverty lead to lifelong depression, learning difficulties, low coping mechanisms

© Phils Photography / Fotolia
Low-income children have irregular brain development and lower standardized test scores, with as much as an estimated 20 percent gap in achievement explained by developmental lags in the frontal and temporal lobes of the brain.
An alarming 22 percent of U.S. children live in poverty, which can have long-lasting negative consequences on brain development, emotional health and academic achievement. A new study, published July 20 in JAMA Pediatrics, provides even more compelling evidence that growing up in poverty has detrimental effects on the brain.

In an accompanying editorial, child psychiatrist Joan L. Luby, MD, at Washington University School of Medicine in St. Louis, writes that "early childhood interventions to support a nurturing environment for these children must now become our top public health priority for the good of all."

In her own research in young children living in poverty, Luby and her colleagues have identified changes in the brain's architecture that can lead to lifelong problems with depression, learning difficulties and limitations in the ability to cope with stress.

Comment: Knowing how the developing brain is negatively impacted by growing up in a low-income household helps to understand the on-going cycle of poverty within families. It explains some of the difficulties people face in attempting to improve their lives and counters the heartless elitist meme that poor people lack the will or desire to change their circumstances, when in truth the system has likely been designed to keep the majority as an under-class to serve those in power.


Water

Heat and high humidity can be a deadly combination

© ThinkStock
Heat and humidity can be a deadly combination.
It's getting hot out there.

As the mercury soars, so too do heat-related deaths -- whether it's a child left too long in a hot car or an elderly person stuck at home with no air conditioning -- heat proves to be a deadly agent every summer.

So, why can heat be so deadly?

Hot weather alone is not dangerous, said Chris Minson, an environmental physiologist at the University of Oregon, Eugene. Instead, it's a combination of hot temperatures, high humidity, and often preexisting health conditions that can push a person's core body temperature to reach the danger zone of 104 F. At that point, the nervous system goes haywire, the heart experiences excessive stress, and organ systems begin to fail.

MIB

Misinformed consent: Introducing Hepatitis C drugs in Georgia

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Trust us, we... er, um... think it'll be good for you.
On May 6 New Eastern Outlook published an article about the new Hepatitis C drugs being introduced to Georgia. It stated that this is another US-imposed programme in which patients will be given experimental drugs which they cannot give their informed consent to taking because not enough information is known about them to give that consent. Georgians will be used as guinea pigs, in other words.

These suggestions produced howls of protest from people working in Georgia's healthcare sector. They insisted that the drugs were safe and the point of the programme was to see if Hep C could be totally eradicated in one go, using Georgians as a sample population. Even Georgia's Health Minister, Dr. David Sergeenko, weighed in by announcing that the new drugs have been approved and "Georgia is not a testing country".

The trouble is, Georgia's Health Minister and the others involved with this programme are not telling the truth. If they don't know this, they should resign. If they do, they should be in jail.

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FDA goes on the attack against essential oils

In September of 2014, the FDA began a coordinated attack on companies that market essential oils. The top brands are dōTERRA and Young Living. Both companies offer essential oils to help manage a variety of symptoms ranging from headaches to anxiety to hyperactivity. Many essential oil users claim to have eliminated the need for over-the-counter medications due to using specific combinations of essential oils to target common maladies.

Back in 2014, Young Living received a warning that you can see on the FDA's website. It seems they had conducted a thorough search of the Internet, including websites, Facebook, Twitter, and Pinterest, and cited instances that Young Living essential oils were mentioned in conjunction with a medical diagnosis. For example, "Eucalyptus Blue essential oil has antiviral and anti-inflammatory properties." And, "Since I have become an avid Young Living essential oil user I have learned all about the anti-microbial properties of so many oils, including ANTI-VIRAL constituents in many of our essential oils."

Comment: It's highly interesting that the FDA has been caught basically rubber-stamping approvals for pharma drugs that have later been found to cause severe side effects and deaths, yet they are now targeting the manufacturers of plant oils that have been in use for centuries. It's not difficult to see the hand of BigPharma in directing this.

FDA uses mafia tactics for the benefit of Big Pharma


Health

Antidepressants combined with NSAIDs increases risk of intracranial hemorrhage

A new study has found that taking antidepressants with a common class of painkillers, known as non-steroidal anti-inflammatory drugs (NSAIDs), increases the user's risk of intracranial haemorrhage (bleeding inside the skull) soon after starting treatment.

Commonly used NSAIDs include ibuprofen and aspirin.

Based on the ongoing concern of a drug interaction, a team of researchers based in Korea compared the risk of bleeding among patients treated with antidepressants with and without NSAIDs.

Using the Korean nationwide health insurance database, their study involved over four million people who were prescribed antidepressants for the first time between 2009 and 2013.

The researchers analyzed the timing of both NSAID prescriptions and hospital records to identify any patients with a first admission of intracranial haemorrhage within 30 days of a new prescription. Factors that could affect the results, such as age, sex, and use of other medications, were taken into account.

Compared with the use of antidepressants alone, the findings showed that a combined use of antidepressants and NSAIDs was linked to a significantly increased risk of bleeding.

Comment: NSAIDs such as aspirin and ibuprofen are associated with stomach bleeding and also cause the body to retain fluids, which may lead to kidney damage. They also increase the risk of heart attack and stroke. Ibuprofen has been linked to dozens of adverse health effects, including anemia, DNA damage, hearing loss, hypertension, and miscarriage.


Bacon n Eggs

Fat is back: The Real Meal Revolution's high-fat diet

© Alamy
'The Real Meal Revolution explains how we can load up on butter, cheese and cream, while staying healthy and – miraculously – losing weight'
Fat, if the past year's headlines are anything to go by, is no longer the enemy. It's back on the menu (the trend for butter-laden Bulletproof coffee, anyone?), back in our kitchens (low-carb "fat bomb" recipes abound), and even back in the good books of US government dietary advisers.

Their report, released in May, declared eating cholesterol-rich foods has very little bearing on the amount of cholesterol in your body. If the US government adopts its advice, it could mean a reversal of the dietary information given to Americans since the 1960s. Big news if you've been itching for a fry-up.

Now a new book by three South Africans, the scientist and ultra-marathon-runner Professor Tim Noakes, the nutritionist Sally-Ann Creed, and the chef Jonno Proudfoot, is about to be published in the UK. It explains how we can load up on butter, cheese and cream, while staying healthy and - miraculously - losing weight.

Comment: It's good that LCHF diets are getting more and more well known. But all the mainstream versions still seem to have something wrong with them: either too many carbs, too many processed foods and additives, or the inclusion of dairy, like this one. At the very least, people trying a diet like this for the first time should stop eating dairy for several weeks before reintroducing it, to see if they experience any negative reactions.


Health

The hidden health dangers of kale have been revealed

© Wikimedia Commons
Curly kale growing in the garden.
People who love kale, cabbage, broccoli and cauliflower often eat these vegetables on a regular basis. But over-indulgence may be dangerous. It may sound strange, but healthy-eating food addicts may be doing themselves harm.

A small study has found that if consumed in prodigious amounts, kale, and other members of the cruciferous family of vegetables to which it belongs, can be dangerous, and it doesn't matter if the kale is organic or not.

Biologist Ernie Hubbard is an alternative medicine researcher, living in Marin County, California. In 2010, he had the opportunity to conduct a study for a Cleveland-based company on a detoxification formula, called ZNatural. Hubbard is a molecular biologist with a background in biochemistry and genetics.

With his background, he was able to develop some tests not usually found in traditional laboratories, including "bio-impedence" analyzers that measure cellular energy and "chelating" formulas like ZNatural. While chelating formulas are controversial, ZNatural proved to be safe.

But it was during the testing phase of the product that Hubbard discovered something quite by accident, and that is the real story. Twenty volunteers were involved in the study conducted by Hubbard, and they happily peed into cups before, during and after the consumption of the ZNatural product.

Hubbard noticed an odd pattern in the testing of the urine samples. Several people had high levels of thallium and cesium in their urine, two heavy metals. "At first, I just thought 'Oh, another one of those.' By the third or fourth, I started scratching my head," Hubbard said.

Ambulance

Doctors searching for clues to child paralysis cases now suspect a different enterovirus

A mysterious outbreak of child paralysis cases previously linked to enterovirus D68 may instead have another cause, doctors at the University of Virginia Children's Hospital are cautioning after determining that a stricken child appeared to be suffering from a different virus.

A 6-year-old girl arrived at UVA Children's Hospital in October after her parents noticed that her right shoulder was drooping and that she was having difficulty using her right hand. She had previously exhibited cold-like symptoms, including a cough, a slight fever and headache. The child's paralysis symptoms were similar to those seen in more than 100 other children during an outbreak of acute flaccid myelitis that began in the summer of 2014.

While enterovirus D68 has been the primary suspect in the paralysis cases, the girl's test results identified a different potential culprit, enterovirus C105. "Surprisingly, it came back with this enterovirus C105, which I'll admit, when it came back, I'd never heard of," said UVA's Ronald B. Turner, MD. "It was just described in the last eight or nine years and it hasn't been seen much around the world. Now, I think you have to be careful with that, because we don't look for it. And you don't see what you don't look for. So it's possible it's out there and it's not being detected because nobody's sending specimens to be tested in this way."

Comment: One thing not being mentioned is the link between the epidemic of child paralysis and vaccinations. It has been reported that all of the afflicted children have been vaccinated with the MMR vaccines, influenza vaccines, and polio vaccines, yet the illness has not been occurring in un-vaccinated children. Paralysis is associated with polio infection and Acute Flaccid Paralysis (AFP) is a class of paralyses that is indistinguishable from the paralysis occurring in thousands within the vaccinated population.


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Some psychiatric drugs seem to affect moral decisions

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A new study in which researchers observed people making moral decisions while taking prescription drugs sheds light on how the neurotransmitters serotonin and dopamine are deeply connected to a variety of human behaviors.

When healthy people were given citalopram, a serotonin-boosting antidepressant, they became significantly harm aversive. In fact, they were willing to pay twice as much to prevent harm to themselves or others compared to people given placebo drugs.

In contrast, when healthy people were given levodopa, a dopamine-boosting Parkinson's drug, they became more selfish, virtually eliminating altruistic behaviors.

The findings provide insight into the neural basis of clinical disorders characterized by a lack of concern for others, such as psychopathy.

Comment: Additional examples of how 'commonly prescribed psychiatric drugs influence moral decisions in healthy people'