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Why people with Down syndrome invariably develop Alzheimer's disease

Amyloid plaques
© Juan Gartner
Amyloid plaques are found in the brains of people with Down syndrome and Alzheimer's disease.
A new study by researchers at Sanford-Burnham reveals the process that leads to changes in the brains of individuals with Down syndrome -- the same changes that cause dementia in Alzheimer's patients. The findings, published in Cell Reports, have important implications for the development of treatments that can prevent damage in neuronal connectivity and brain function in Down syndrome and other neurodevelopmental and neurodegenerative conditions, including Alzheimer's disease.

Down syndrome is characterized by an extra copy of chromosome 21 and is the most common chromosome abnormality in humans. It occurs in about one per 700 babies in the United States, and is associated with a mild to moderate intellectual disability. Down syndrome is also associated with an increased risk of developing Alzheimer's disease. By the age of 40, nearly 100 percent of all individuals with Down syndrome develop the changes in the brain associated with Alzheimer's disease, and approximately 25 percent of people with Down syndrome show signs of Alzheimer's-type dementia by the age of 35, and 75 percent by age 65. As the life expectancy for people with Down syndrome has increased dramatically in recent years -- from 25 in 1983 to 60 today -- research aimed to understand the cause of conditions that affect their quality of life are essential.

"Our goal is to understand how the extra copy of chromosome 21 and its genes cause individuals with Down syndrome to have a greatly increased risk of developing dementia," said Huaxi Xu, Ph.D., professor in the Degenerative Diseases Program and senior author of the paper. "Our new study reveals how a protein called sorting nexin 27 (SNX27) regulates the generation of beta-amyloid -- the main component of the detrimental amyloid plaques found in the brains of people with Down syndrome and Alzheimer's. The findings are important because they explain how beta-amyloid levels are managed in these individuals."
Bulb

Ebola scare motivating interest in immune system functioning and alternative therapies

ebola
© FP Dominique Faget
We are witnessing a stunning reversal of events in the face of the present Ebola scare consuming North America. The drum beatings of fear played all to often by the mainstream media have given way to a symphony of personal empowerment, education, and a mass social movement to take back our health freedom.

The threat of Ebola initially grabbed headlines and paralyzed millions who lacked understanding. Answers were sought amidst the fear peddling and confusion yet few were being found. A disheartened population is now storming the 'alternative' media and independent health networks, websites, and radio shows for direction. What they are finding is currently propelling us all into a new, decentralized health paradigm.

To the disbelief of pharmaceutical companies, people across North America are taking the time to understand what their immune system is. They are then shocked to find out that it's weak, damaged, and under attack daily. Like true warriors, most are activated into action and begin researching.

Comment: One of the best ways to improve the immune system is to begin to de-toxify the body, eliminating inflammatory foods, GMO ingredients, gluten and casein. Following a ketogenic diet improves immune system functioning while also ameliorating and even preventing a host of diseases. Here are some suggestions to begin implementing now:

The Ketogenic Diet - An Overview

Vitamin C - A cure for Ebola

Natural allopathic treatment modalities for Ebola

Scientists stumble across the obvious treatment for Ebola: tobacco

Dollar

Anger over 'cash for diagnoses' dementia plan in England

Cash for Diagnosis
© Alamy
Ministers have pledged to dramatically improve rates of dementia diagnosis, which has led to the new scheme.
Family doctors will be paid £55 for every patient they diagnose with dementia under a new NHS England scheme which has been condemned as an "ethical travesty".

Leading GPs said the national project amounted to "cash for diagnoses" - allowing doctors to make a direct profit if they classify patients as suffering from dementia.

In some parts of the country, NHS authorities have gone still further - offering family doctors £200 for each new diagnosis made, The Telegraph can reveal.

Patients groups and doctors have condemned the schemes, saying they amounted to a "bounty on the head" of the most vulnerable, which could cloud the judgements of those making diagnoses.

Under the national scheme, doctors can receive the £55 payment for every extra patient given a diagnosis of dementia in the six months ending in March.

GPs qualify for payment if they diagnose the patients themselves - with no checks on whether their assessment is correct - or if they update their records when their patients receive a diagnosis in hospital.

Family doctors are already financially rewarded for carrying a host of medical checks, with a portion of their pay related to tasks such as taking blood pressure, measuring cholesterol and carrying out tests for conditions such as diabetes.

But the scheme is understood to be the first national initiative to offer doctors financial rewards for diagnosing patients with any condition.

It follows pledges by ministers to dramatically improve rates of dementia diagnosis.
Bandaid

World Health Organization declares Nigeria is Ebola-free, holds lessons for others

© REUTERS/Stringer
Students of Goverment Secondary School Garki wash their hands, as school resumes in Abuja September 22, 2014.
Nigeria was declared free of the deadly Ebola virus on Monday after a determined doctor and thousands of officials and volunteers helped end an outbreak still ravaging other parts of West Africa and threatening the United States and Spain.

Caught unawares when a diplomat arrived with the disease from Liberia, authorities were alerted by Doctor Ameyo Adadevoh, who diagnosed it, kept him in hospital despite protests from him and his government and later died from Ebola herself.

They then set about trying to contain it in an overcrowded city of 21 million where it could easily have turned a doomsday scenario if about 300 people who had been in direct or indirect contact with him not been traced and isolated.

"This is a spectacular success story," Rui Gama Vaz from the World Health Organization (WHO) told a news conference in the capital Abuja, where officials broke into applause when he announced that Nigeria had shaken off the disease.

"It shows that Ebola can be contained, but we must be clear that we have only won a battle, the war will only end when West Africa is also declared free of Ebola."

This year's outbreak of the highly infectious hemorrhagic fever thought to have originated in forest bats is the worst on record.
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Research shows bitter melon kills cancer and stops diabetes

bitter melon
© Healthy Hobbit
According to Dr. Frank Shallenberger, when it comes to fighting cancer, he's always looking for natural substances that interrupt the odd metabolism of cancer cells. Some of his discoveries include resveratrol, green tea, Seanol, and others. Most recently, he found a fruit that was effective in killing pancreatic cancer cells. The fruit is called "bitter melon" and is popular in Okinawa, Japan.

When bitter melon juice is diluted to 5% in water, it proved itself to be incredibly damaging to pancreatic cancer cell lines. According to researchers, bitter melon juice reduced the viability of two cancer cell lines by 90% and killed the remaining two lines at a rate of 98%.

So, great, these studies work in cancer cells in a dish. But do they work in animals? Will they work in people? Apparently yes. University of Colorado researchers administered bitter melon doses to mice and found a 64% reduction in pancreatic tumor size without any kind of side effect.
Bacon n Eggs

Breakfast rich in protein boosts dopamine and diminishes food cravings

egg_sausage_bacon
© www.samscornerdeli.com
New research shows that eating a good breakfast - particularly one rich in protein - boosts a critical neurotransmitter, which may lower food cravings later in the day.

The research comes as the Centers for Disease Control and Prevention (CDC) reports that many teens skip breakfast and adolescent obesity has quadrupled in the last 30 years.

Dr. Heather Leidy, an assistant professor of nutrition and exercise physiology who led the study, said:

"Our research showed that people experience a dramatic decline in cravings for sweet foods when they eat breakfast.

However, breakfasts that are high in protein also reduced cravings for savory - or high-fat - foods.

On the other hand, if breakfast is skipped, these cravings continue to rise throughout the day."

Comment: Many people skip breakfast or load up on high-carb foods. Skipping the first meal of the day causes you to eat more at lunch and primes your brain to seek out unhealthier, higher-calorie foods. Carbohydrates cause insulin levels to spike, then precipitously drop, which sets up a roller-coaster of food cravings. One of the best ways to improve health and metabolism is to switch to a ketogenic diet, which is rich in saturated fat, with moderate protein intake and minimal carbohydrates. This diet also helps to alleviate and prevent a host of diseases. See:

High-fat low-carb ketogenic diets beginning to earn mainstream respect

The Ketogenic Diet - An Overview

The art and science of nutritional ketosis Stephen Phinney

Hearts

How yoga heals the diseased heart

What if the simple act of doing yoga could heal your diseased heart?

A new study titled, "Effects of Yoga in Patients with Chronic Heart Failure: A Meta-Analysis," reveals that this ancient practice, ever-increasing in popularity in the West, has profound benefits to those who are suffering from cardiovascular disease.

Previous to this study, the idea that yoga could heal a diseased heart was considered strictly theoretical, which is what motivated a team of Portuguese researchers to put the concept to the test.

The team performed a meta-analysis of the published research on the topic of how yoga might improve exercise capacity and health-related quality of life in patients with chronic heart failure.

Comment: Why Yoga? Healing research:

Whistle

Dr. Huber's brave crusade against Biotech

Dr. Don Huber was hit by a car last night. He is a whistle blower in the food world and someone I have had the honor of knowing.

Dr. Huber is Professor Emeritus of Plant Pathology at Purdue University, a land grant institution, and has been studying plants for 55 years. He has received various awards for his scientific accomplishments and contributions to government.

He was Cereal Pathologist at the University of Idaho for 8 years before joining the Department of Botany & Plant Pathology at Purdue University in 1971.

His agricultural research the past 50 years has focused on the epidemiology and control of soil borne plant pathogens with emphasis on microbial ecology, cultural and biological controls, and physiology of host parasite relationships.

He's in his 80s, and he is also a father, a grandfather and has had a 41-year military career as a retired Colonel.

He is someone I have turned to in this work when I read,"Pesticides may be putting young children at risk of cancer." Other headlines have suggested that pesticides are linked to Parkinson's, autism and other conditions.

Comment: Read more about Dr. Huber's extensive research: Toxicology expert speaks out about Roundup and GMOs:

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Experts questioned the validity of Ebola testing way back in 1977

lab
© photopin cc
The experts were expressing grave doubts all the way back in 1977. Right at the beginning.

They were questioning the validity of standard tests used to diagnose Ebola - tests being the only way to say the virus is present in humans.

Of course, if the tests are unreliable, the whole premise of an epidemic caused by a single virus has no value. It's an unwarranted assumption.

At that point, you can look for illness and death stemming from a number of causes. And you're driven to the fact that, in Africa, large numbers of people have been dying for a very long time, for reasons that have nothing to do with germs:

Grinding poverty, war, starvation and severe malnutrition, contaminated water, pesticides, lack of basic sanitation, extreme overcrowding, stolen farm land, toxic medicines, and so on.

Not a viral epidemic.
Health

Cold sores increase risk of dementia


Infection with herpes simplex virus increases the risk of Alzheimer's disease, researchers claim.
Infection with herpes simplex virus increases the risk of Alzheimer's disease. Researchers at Umeå University, Sweden, claim this in two studies in the journal Alzheimer's & Dementia.

"Our results clearly show that there is a link between infections of herpes simplex virus and the risk of developing Alzheimer's disease. This also means that we have new opportunities to develop treatment forms to stop the disease," says Hugo Lövheim, associate professor at the Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, who is one of the researchers behind the study.

Alzheimer's disease is the most common among the dementia diseases. In recent years research has increasingly indicated that there is a possible connection between infection with a common herpes virus, herpes simplex virus type 1, and Alzheimer's disease. A majority of the population carries this virus. After the first infection the body carries the virus throughout your lifetime, and it can reactivate now and then and cause typical mouth ulcer. The hypothesis which links the herpes virus and Alzheimer's disease is based on that a weakened immune system among the elderly creates opportunities for the virus to spread further to the brain. There this can in turn start the process which results in Alzheimer's disease.

Comment: Some helpful articles on Alzheimer's disease:

Food for thought: Eat your way to dementia - sugar and carbs cause Alzheimer's Disease

Ketogenic Diet Reduces Symptoms of Alzheimer's

The Ketogenic Diet - An Overview

Ketogenic Diet (high-fat, low-carb) Has Neuroprotective and Disease-modifying Effects

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