
© The Cancer Genome AtlasA drawing depicting a DNA molecule unwinding from a chromosome inside the nucleus of a cell.
Bacterial DNA may integrate into the human genome more readily in tumors than in normal human tissue, scientists have found.
The researchers, affiliated with the University of Maryland School of Medicine's Institute for Genome Sciences, analyzed genomic sequencing data available from the Human Genome Project, the 1,000 Genomes Project and The Cancer Genome Atlas.
They considered the phenomenon of lateral gene transfer (LGT), the transmission of genetic material between organisms in a manner other than than traditional reproduction.
Scientists have already shown that bacteria can transfer DNA to the genome of an animal.
The researchers found evidence that lateral gene transfer is possible from bacteria to the cells of the human body, known as human somatic cells.
They found that bacterial DNA was more likely to integrate in the genome in tumor samples than in normal, healthy somatic cells. The phenomenon might play a role in cancer and other diseases associated with DNA damage.
"Advances in genomic and computational sciences are revealing the vast ways in which humans interact with an ever-present and endlessly diverse planet of microbes," says Matt Kane, program director in the National Science Foundation's Division of Environmental Biology in its Directorate for Biological Sciences, which funded the research.
Comment: In fact, it can happen in a matter of months:
Last Ice Age took just SIX months to arrive