
© AlamyHarvard University has, for the first time, managed to manufacture the millions of beta cells required for transplantation.
A cure for diabetes could be imminent after scientists discovered how to make huge quantities of insulin-producing cells, in a breakthrough hailed as significant as antibiotics.
Harvard University has, for the first time, managed to manufacture the millions of beta cells required for transplantation.
It could mean the end of daily insulin injections for the 400,000 people in Britain living with Type 1 diabetes.
And it marks the culmination of 23-years of research for Harvard professor Doug Melton who has been trying to find a cure for the disease since his son Sam was diagnosed with Type 1 diabetes as a baby.
"We are now just one pre-clinical step away from the finish line," said Prof Melton.
Asked about his children's reaction he said: "I think like all kids, they always assumed that if I said I'd do this, I'd do it,
"It was gratifying to know that we can do something that we always thought was possible."
The stem cell-derived beta cells are presently undergoing trials in animal models, including non-human primates, where they are still producing insulin after several months, Prof Melton said.
Comment: Torpor is a condition that can happen naturally from hypothermia. It shuts down most non-vital body processes and dramatically slows down the metabolism. The torpor state would be achieved by lowering body temperatures to somewhere between 89 and 93 degrees Fahrenheit. For every single degree the body temperature drops, its metabolic rate drops 5 to 7 percent. Researchers hope to get a 10 degree drop which would mean a 50 to 70 percent reduction in metabolic rate. The coma would be induced by letting the spaceship cool down in the freezing cold of space bringing the astronauts' body temperatures down, too. During interplanetary transit, the crew would receive low-level electrical impulses to key muscle groups to prevent muscles wasting away while in hibernation.