Four other injured workers were airlifted to a hospital.
The Coast Guard in New Orleans says it's investigating a fire on an oil rig in the Gulf of Mexico, according to the Associated Press.
KHOU-TV reports that two people are dead and two more people are missing after the explosion at the platform in the Gulf.
Four people have also been airlifted to a hospital and said to be "in critical condition," according to KHOU-TV and the Associated Press.
"Jefferson Parish Councilman Chris Roberts said the rig in question is a shallow water platform in the Gulf of Mexico. It is near West Cote Blanche Bay, south of New Iberia on the south-central Louisiana coast," WWLTV reported.
Petty Officer 3rd Class Jonathan Lally, a spokesman for the Coast Guard, did not immediately have information on the conditions of those taken to hospitals, the AP reported.
The rig, a production platform owned by Black Elk Energy, is about 25 miles southeast of Grand Isle, La.
Lally says two helicopters, an airplane and small boats were sent to the area on Friday. He did not know if the fire caused by the explosion had been put out yet.
The platform is a production platform, unlike the Deepwater Horizon rig, which was drilling an exploratory well in mile-deep water well to the east of Friday's reported explosion.